ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2021
Does the Loudness Dependence of Auditory Evoked Potential Predict Response to Selective Serotonin Reuptake Inhibitors?: A Meta-analysis.
Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Hormonal contraceptives and EEG biomarkers for antidepressant treatment response in women.Communications medicine · 2026Article
- Application of Treatment Response Biomarkers from Major Depression to Perinatal Depression.Journal of personalized medicine · 2025Review
- Sound intensity-dependent cortical activation: implications of the electrical and vascular activity on auditory intensity.Cognitive neurodynamics · 2025Article
- Basic stimulus processing alterations from top-down cognitive control in depression drive independent temporal components of multi-echo naturalistic fMRI data.Translational psychiatry · 2025Article
- Hormonal contraceptive use is associated with reduced central serotonergic activity indexed by the loudness dependence of auditory evoked potentials.Frontiers in human neuroscience · 2025Article
- Loudness dependence of auditory evoked potentials reflects trait anxiety and harm avoidance in healthy adults: an exploratory study.Frontiers in human neuroscience · 2025Article
- Loudness dependence of the auditory evoked potential: temporal stability, associations to sociodemographic variables, and functional significance-implications for clinical research.Frontiers in human neuroscience · 2025Article
- Technical and clinical considerations for electroencephalography-based biomarkers for major depressive disorder.Npj mental health research · 2023Review
- Relationship of loudness-dependent auditory evoked potentials with change-related cortical responses.PloS one · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveLoudness of dependence of the auditory evoked potential (LDAEP) is an electroencephalogram-based measure that represents amplitude changes of auditory evoked potentials in primary auditory cortex. Several narrative reviews argued that pre-treatment LDAEP values predict responses to selective serotonin reuptake inhibitors (SSRIs). This study aims to quantify the overall relationship between baseline LDAEP values and treatment response to SSRIs in patients with depression and generalized anxiety disorders, evidenced by clinical symptoms reductions, across multiple studies.
methodsIn our meta-analysis, seven articles with a total sample of 241 patients were included.
resultsOur results showed that stronger baseline LDAEP values predicted favorable response to SSRIs for depression and anxiety, with a moderate effect size.
conclusionThe current results support the idea that LDAEP is a promising biomarker for SSRIs treatment prediction in patients with depression and generalized anxiety disorder.
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