Evidence map›Paper›PMID 33888649›Full record

ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2021

Personalization of Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depressive Disorder According to the Existing Psychiatric Comorbidity.

Po-Han Chou, Yen-Feng Lin, Ming-Kuei Lu, Hsin-An Chang, Che-Sheng Chu, Wei Hung Chang, Taishiro Kishimoto, Alexander T Sack, Kuan-Pin Su

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05723172 (40Hz tACS in Treating Cognitive Function and Modulating Neurophysiology of Patients With Alzheimer's Disease), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05723172 naunknown statusnot on this mapstarted 2023, after this paper: background citation

40Hz tACS in Treating Cognitive Function and Modulating Neurophysiology of Patients With Alzheimer's Disease: a Triple Blind Randomized Sham-controlled Trial

TypeinterventionalSponsorChe-Sheng ChuRan2023 to 2025Enrolled48ConditionsAlzheimer DiseaseArmsactive tACS, sham tACS
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  18. The Korean Medication Algorithm Project for Depressive Disorder 2021: Comparisons with Other Treatment Guidelines.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022
    Review
  19. Article
  20. Korean Medication Algorithm for Depressive Disorder 2021, Fourth Revision: An Executive Summary.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 3 countries.

Po-Han ChouDepartment of Psychiatry, China Medical University Hsinchu Hospital, China Medical University, Hsinchu, Taiwan.ORCID https://orcid.org/0000-0002-4148-457X
Yen-Feng LinTaiwan Allied Clinics for Integrative TMS, Taipei, Taiwan.ORCID https://orcid.org/0000-0003-3017-6026
Ming-Kuei LuPh.D. Program for Translational Medicine, College of Medicine, China Medical University, Taichung, Taiwan.ORCID https://orcid.org/0000-0002-2768-4399
Hsin-An ChangDepartment of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.ORCID https://orcid.org/0000-0001-5572-7109
Che-Sheng ChuDepartment of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0002-6911-1839
Wei Hung ChangDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0002-5964-106X
Taishiro KishimotoDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0003-0557-8648
Alexander T SackDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands.ORCID https://orcid.org/0000-0002-1471-0885
Kuan-Pin SuDepartment of Psychiatry, China Medical University Hospital, China Medical University, Taichung, Taiwan.ORCID https://orcid.org/0000-0002-4501-2502
China Medical University · TWNational Yang Ming Chiao Tung University · TWKaohsiung Medical University · TWKeio University · JPMaastricht University Medical Centre · NLNational Cheng Kung University Hospital · TWTri-Service General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repetitive transcranial magnetic stimulation (rTMS) and intermittent theta-burst stimulation (iTBS) are evidenced-based treatments for patients with major depressive disorder (MDD) who fail to respond to standard first-line therapies. However, although various TMS protocols have been proven to be clinically effective, the response rate varies across clinical applications due to the heterogeneity of real-world psychiatric comorbidities, such as generalized anxiety disorder, posttraumatic stress disorder, panic disorder, or substance use disorder, which are often observed in patients with MDD. Therefore, individualized treatment approaches are important to increase treatment response by assigning a given patient to the most optimal TMS treatment protocol based on his or her individual profile. This literature review summarizes different rTMS or TBS protocols that have been applied in researches investigating MDD patients with certain psychiatric comorbidities and discusses biomarkers that may be used to predict rTMS treatment response. Furthermore, we highlight the need for the validation of neuroimaging and electrophysiological biomarkers associated with rTMS treatment responses. Finally, we discuss on which directions future efforts should focus for developing the personalization of the treatment of depression with rTMS or iTBS.

Indexed as

Brain stimulationDepressionRepetitive transcranial magnetic stimulationrTMSTBS.Theta-burst stimulation

Identifiers

PMID33888649
PMCPMC8077054
OpenAlexW3155331051

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.