ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Reciprocal Lateral Hypothalamic and Raphe GABAergic Projections Promote Wakefulness.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Sleep circuit modulation: from animal models to human translation.Brain : a journal of neurology · 2026Review
- Hypothalamic control of arousal.Reviews in endocrine & metabolic disorders · 2026Review
- Lateral hypothalamus to dorsal raphe nucleus projections modulate intraspecific attack behavior in male mice.iScience · 2026Article
- Dysfunction of the rostral lateral septum GABAergic neurons induces mania-like behavior in male mice.Translational psychiatry · 2025Article
- Ethanol-induced rapid eye movement sleep suppression in rats: Comparison with subtype-selective GABAJournal of psychopharmacology (Oxford, England) · 2025Article
- The role and interaction of hypothalamic-related neurotransmitters in migraine.The journal of headache and pain · 2025Review
- Temporal Association Cortex Gates Sound-Evoked Arousal from NREM Sleep.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Serotonin neurons integrate GABA and dopamine inputs to regulate meal initiation.Metabolism: clinical and experimental · 2025Article
- Regulation of wakefulness by neurotensin neurons in the lateral hypothalamus.Experimental neurology · 2025Article
- A hypothalamus-lateral periaqueductal gray GABAergic neural projection facilitates arousal following sevoflurane anesthesia in mice.CNS neuroscience & therapeutics · 2024Article
- 5-HT Neurons Integrate GABA and Dopamine Inputs to Regulate Meal Initiation.bioRxiv : the preprint server for biology · 2024Article
- A midbrain GABAergic circuit constrains wakefulness in a mouse model of stress.Nature communications · 2024Article
- Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus.Nature neuroscience · 2023Article
- Neuro-orchestration of sleep and wakefulness.Nature neuroscience · 2023Review
- Differential Serotonergic Modulation of Synaptic Inputs to the Olfactory Cortex.International journal of molecular sciences · 2023Article
- Hypothalamic GABAergic neurocircuitry in the regulation of energy homeostasis and sleep/wake control.Medical review (2021) · 2022Review
- Spatiotemporal Control of Noradrenaline-Dependent Synaptic Transmission in Mouse Dorsal Raphe Serotonin Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Differential Serotonergic Modulation of Principal Neurons and Interneurons in the Anterior Piriform Cortex.Frontiers in neuroanatomy · 2022Article
- Activity of the Lateral Hypothalamus during Genetically Determined Absence Seizures.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 5 countries.
Funding
Abstract
The lateral hypothalamus (LH), together with multiple neuromodulatory systems of the brain, such as the dorsal raphe nucleus (DR), is implicated in arousal, yet interactions between these systems are just beginning to be explored. Using a combination of viral tracing, circuit mapping, electrophysiological recordings from identified neurons, and combinatorial optogenetics in mice, we show that GABAergic neurons in the LH selectively inhibit GABAergic neurons in the DR, resulting in increased firing of a substantial fraction of its neurons that ultimately promotes arousal. These DR
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.