ArticleScience (New York, N.Y.)2021
Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 2 pooled it
12.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
103 citing papers in PubMed, 2 syntheses or guidelines pooled it, 160 citations in OpenAlex.
- Pooled it
- Biomarkers of Genotoxicity in Medical Workers Exposed to Low-Dose Ionizing Radiation: Systematic Review and Meta-Analyses.International journal of molecular sciences · 2021Pooled it
- Teclistamab versus lenalidomide-dexamethasone in high-risk smoldering multiple myeloma: a randomized phase 2 trial.Nature medicine · 2026Trial
- Deeper response predicts better outcomes in high-risk-smoldering-myeloma: results of the I-PRISM phase II clinical trial.Nature communications · 2025Trial
- Genomics and Multi-Omics to Guide Clinical Management in Thyroid Cancer.International journal of molecular sciences · 2026Review
- Therapy-Related Mutational Signatures in Subsequent Neoplasms among Survivors of Childhood Cancer.Cancer discovery · 2026Article
- Radioiodine-Refractory Differentiated Thyroid Cancer: Definition, Molecular Mechanisms, and Advances in Precision Therapy.Cancer innovation · 2026Review
- Environmental exposures and multiple myeloma risk: A contemporary review of epidemiologic associations and mechanistic plausibility.Blood reviews · 2026Review
- Understanding and overcoming innate and acquired MAPK inhibition resistance in anaplastic thyroid cancer.Cell reports. Medicine · 2026Article
- Restorative effect of Rehmanniae radix praeparata on T-cell and NK-cell-mediated immune reconstitution in mice following radiation-induced injury.Journal of radiation research · 2026Article
- Post-Chornobyl thyroid papillary carcinomas display distinct pastScientific reports · 2026Article
- Signatures of Radiation-Induced Stress and Putative Selection on Immune Targets in Chornobyl Wolves.Molecular ecology · 2026Article
- The influence of age-independent somatic driver alterations on clinical outcomes in paediatric and young adult thyroid cancer.European thyroid journal · 2026Article
- Correlations of m6A methylation-related mRNAs with thyroid cancer.Scientific reports · 2026Article
- DNA Damage and Repair in Thyroid Physiology and Disease.Endocrine reviews · 2026Review
- TSH suppression therapy from an individualized perspective: from mechanism to clinical decision-making.Frontiers in endocrinology · 2026Review
- Unravelling the rise in thyroid cancer incidence and addressing overdiagnosis.Nature reviews. Endocrinology · 2026Review
- Review
- Dedifferentiation and Redifferentiation of Follicular-Cell-Derived Thyroid Carcinoma: Mechanisms and Therapeutic Implications.Biomedicines · 2025Review
- INDIVIDUAL THYROID DOSE ESTIMATES FOR THE GENOMIC STUDY OF FOLLICULAR CARCINOMAS AND ADENOMAS IN PARTICIPANTS OF THE CHORNOBYL TISSUE BANK.Problemy radiatsiinoi medytsyny ta radiobiolohii · 2025Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors at 10 institutions in 4 countries.
Lindsay M MortonRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. chanocks@mail.nih.gov mortonli@mail.nih.gov.ORCID https://orcid.org/0000-0001-9767-2310
Danielle M KaryadiLaboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0003-4164-5625
Chip StewartBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID https://orcid.org/0000-0003-2245-9552
Tetiana I BogdanovaLaboratory of Morphology of the Endocrine System, V. P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv 04114, Ukraine.ORCID https://orcid.org/0000-0001-5119-0236
Eric T DawsonLaboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0001-5448-1653
Mia K SteinbergCancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0001-7642-5265
Jieqiong DaiCancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, USA.
Stephen W HartleyLaboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0001-6584-005X
Sara J SchonfeldRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0002-4368-4647
Joshua N SampsonBiostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
Yosef E MaruvkaBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Vidushi KapoorCancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, USA.
Dale A RamsdenDepartment of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID https://orcid.org/0000-0003-1575-4748
Juan Carvajal-GarciaCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID https://orcid.org/0000-0001-7257-3674
Charles M PerouLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID https://orcid.org/0000-0001-9827-2247
Joel S ParkerDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID https://orcid.org/0000-0003-2080-6901
Marko KrznaricDepartment of Surgery and Cancer, Imperial College London, Charing Cross Hospital, London W6 8RF, UK.ORCID https://orcid.org/0000-0001-6776-1136
Meredith YeagerCancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0003-3871-2225
Joseph F BolandCancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, USA.
Amy HutchinsonCancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0002-4962-2711
Belynda D HicksCancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0001-8014-4888
Casey L DagnallCancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0001-7334-4718
Julie M Gastier-FosterNationwide Children's Hospital, Biospecimen Core Resource, Columbus, OH 43205, USA.ORCID https://orcid.org/0000-0001-7141-8031
Jay BowenNationwide Children's Hospital, Biospecimen Core Resource, Columbus, OH 43205, USA.ORCID https://orcid.org/0000-0001-6861-9043
Olivia LeeLaboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0001-5389-6267
Mitchell J MachielaIntegrative Tumor Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0001-6538-9705
Elizabeth K CahoonRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0002-8028-0588
Alina V BrennerRadiation Effects Research Foundation, Hiroshima 732-0815, Japan.ORCID https://orcid.org/0000-0002-8556-3907
Kiyohiko MabuchiRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0002-8867-8777
Vladimir DrozdovitchRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0002-7952-379X
Sergii MasiukRadiological Protection Laboratory, Institute of Radiation Hygiene and Epidemiology, National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Kyiv 04050, Ukraine.
Mykola ChepurnyRadiological Protection Laboratory, Institute of Radiation Hygiene and Epidemiology, National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Kyiv 04050, Ukraine.
Liudmyla Yu ZurnadzhyLaboratory of Morphology of the Endocrine System, V. P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv 04114, Ukraine.
Maureen HatchRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
Amy Berrington de GonzalezRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0002-7332-8387
Gerry A ThomasDepartment of Surgery and Cancer, Imperial College London, Charing Cross Hospital, London W6 8RF, UK.ORCID https://orcid.org/0000-0002-5516-5799
Mykola D TronkoDepartment of Fundamental and Applied Problems of Endocrinology, V. P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv 04114, Ukraine.ORCID https://orcid.org/0000-0001-7421-0981
Gad GetzBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID https://orcid.org/0000-0002-0936-0753
Stephen J ChanockLaboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. chanocks@mail.nih.gov mortonli@mail.nih.gov.ORCID https://orcid.org/0000-0002-2324-3393
National Cancer Institute · USLeidos (United States) · USUniversity of North Carolina at Chapel Hill · USBroad Institute · USV.P. Komisarenko Institute of Endocrinology and Metabolism · UACharing Cross Hospital · GBNationwide Children's Hospital · USState Institution «Academician O.F.Vozianov Institute of Urology of the National Academy of Medical Sciences of Ukraine» · UANvidia (United States) · USRadiation Effects Research Foundation · JP
Funding
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MStudies of Populations Exposed to Environmental Sources of RadiationZIACP010132 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI CAHOON, ELIZABETH · 2009 to 2025
$35.2MStructural determinants of Pol theta functionP01CA247773 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DALE A RAMSDEN · 2020 to 2026
$15.2MThe Role of DNA Synthesis in Nonhomologous End JoiningR01CA097096 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DALE A RAMSDEN · 2003 to 2026
$5.5MThe Chernobyl Tissue Bank - Coordinating CenterU24CA082102 · NCI · UNIVERSITY OF WALES, SWANSEA · PI THOMAS, GERALDINE ANNE · 2000 to 2021
$4.6MPolymerase Theta Mediated End Joining: Mechanism and Essential Functions in Repair of Chromosome BreaksR01CA222092 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RAMSDEN, DALE A · 2018 to 2021
$1.8MDNA Polymerases in Nonhomologous End JoiningU01CA097096 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RAMSDEN, DALE A · 2019 to 2022
$1.4MIntramural NIH HHS ZIA CP010132NCI NIH HHS P01 CA247773NCI NIH HHS R01 CA097096NCI NIH HHS R01 CA222092NCI NIH HHS U01 CA097096NCI NIH HHS U24 CA082102NIEHS NIH HHS P30 ES010126
Abstract
The 1986 Chernobyl nuclear power plant accident increased papillary thyroid carcinoma (PTC) incidence in surrounding regions, particularly for radioactive iodine (
Indexed as
Chernobyl Nuclear AccidentMutationAdolescentAdultChildChild, PreschoolDNA Copy Number VariationsEpigenomeFemaleGene Expression ProfilingGenes, rasGenetic VariationHumansInfantIodine RadioisotopesLoss of HeterozygosityBRAF protein, humanIodine-131Iodine RadioisotopesProto-Oncogene Proteins B-raf
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.