ArticleScience (New York, N.Y.)2021
Lack of transgenerational effects of ionizing radiation exposure from the Chernobyl accident.
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Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
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Who cites it
46 citing papers in PubMed, 95 citations in OpenAlex.
- Artificial "zombie" cells: An emerging platform for targeted drug delivery and disease treatment.Acta pharmaceutica Sinica. B · 2026Review
- A sibling study of variation in parental mutation rates.bioRxiv : the preprint server for biology · 2026Article
- Detection of germline variants in human population chronically exposed to high level natural background radiation in Kerala coast.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2026Article
- From survival of irradiated mice to modern molecular insights: a seventy-year journey in radiobiology at the institute of biophysics, Czech academy of sciences.European biophysics journal : EBJ · 2025Review
- Behavioural changes in high school students and their parents, following their participation in seminars on discrimination and prejudice regarding radiation exposure: a qualitative study on the 'GU-GU-RU' project.BMC public health · 2025Article
- Overview and future studies of potential hereditary effects of parental exposure to atomic bomb radiation on their offspring.Carcinogenesis · 2025Review
- Symposium report-ethical and social considerations regarding return of secondary findings in atomic bomb survivors.Carcinogenesis · 2025Article
- Risk of clonal hematopoiesis in families exposed to radiation following the Chornobyl accident.Carcinogenesis · 2025Article
- Evidence for a transgenerational mutational signature from ionizing radiation exposure in humans.Scientific reports · 2025Article
- Dose Reconstruction for Epidemiological Studies among Ukrainian Chernobyl Cleanup Workers.Radiation research · 2024Article
- DNA Damage and Repair in PBMCs after Internal Ex Vivo Irradiation with [International journal of molecular sciences · 2024Article
- A Historical Survey of Key Epidemiological Studies of Ionizing Radiation Exposure.Radiation research · 2024Review
- Radiotherapy and Testicular Function: A Comprehensive Review of the Radiation-Induced Effects with an Emphasis on Spermatogenesis.Biomedicines · 2024Review
- Effects of urban-induced mutations on ecology, evolution and health.Nature ecology & evolution · 2024Review
- Environmental radiation exposure at Chornobyl has not systematically affected the genomes or chemical mutagen tolerance phenotypes of local worms.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Quantitative and qualitative mutational impact of ionizing radiation on normal cells.Cell genomics · 2024Article
- Cohort study profile: a cohort of Korean atomic bomb survivors and their offspring.Epidemiology and health · 2024Article
- Sex differences in radiation research.International journal of radiation biology · 2024Article
- Is increased mutation driving genetic diversity in dogs within the Chornobyl exclusion zone?PloS one · 2024Article
- 2022 Fukushima Medical University International Symposium on the Fukushima Health Management Survey Build Back Better, Together. "Science for Society: Advancing Fukushima's Well-Being".Fukushima journal of medical science · 2024Article
Corrections and comments
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Authors and funding
38 authors at 9 institutions in 7 countries.
Meredith Yeager *Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA. chanocks@mail.nih.gov yeagerm@mail.nih.gov.ORCID https://orcid.org/0000-0003-3871-2225
Mitchell J Machiela *Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.ORCID https://orcid.org/0000-0001-6538-9705
Prachi KothiyalDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.ORCID https://orcid.org/0000-0002-5457-3029
Michael DeanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.ORCID https://orcid.org/0000-0003-2234-0631
Clara BodelonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.ORCID https://orcid.org/0000-0002-6578-2678
Shalabh SumanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
Mingyi WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.ORCID https://orcid.org/0000-0001-9419-4384
Lisa MirabelloDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
Chase W NelsonBiodiversity Research Center, Academia Sinica, Taipei, 11529, Taiwan.ORCID https://orcid.org/0000-0001-6287-1598
Weiyin ZhouDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.ORCID https://orcid.org/0000-0002-0467-3064
Cameron PalmerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
Bari BallewDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
Leandro M ColliDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.ORCID https://orcid.org/0000-0001-6928-1195
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.ORCID https://orcid.org/0000-0003-0074-1098
Casey DagnallDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.ORCID https://orcid.org/0000-0001-7334-4718
Amy HutchinsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.ORCID https://orcid.org/0000-0002-4962-2711
Vibha VijDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.ORCID https://orcid.org/0000-0002-1411-0257
Yosi MaruvkaBroad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Maureen HatchDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
Iryna IllienkoNational Research Centre for Radiation Medicine, 53 Yu. Illienka Street, Kyiv, 04050, Ukraine.ORCID https://orcid.org/0000-0003-4405-0328
Yuri BelayevNational Research Centre for Radiation Medicine, 53 Yu. Illienka Street, Kyiv, 04050, Ukraine.ORCID https://orcid.org/0000-0001-8927-1859
Nori NakamuraDepartment of Molecular Biosciences, Radiation Effects Research Foundation, 5-2 Hijiyama Park, Minami-ku, Hiroshima, 732-0815, Japan.ORCID https://orcid.org/0000-0001-7901-5085
Vadim ChumakNational Research Centre for Radiation Medicine, 53 Yu. Illienka Street, Kyiv, 04050, Ukraine.ORCID https://orcid.org/0000-0001-6045-9356
Elena BakhanovaNational Research Centre for Radiation Medicine, 53 Yu. Illienka Street, Kyiv, 04050, Ukraine.ORCID https://orcid.org/0000-0003-3960-5069
David BelyiNational Research Centre for Radiation Medicine, 53 Yu. Illienka Street, Kyiv, 04050, Ukraine.ORCID https://orcid.org/0000-0002-2416-2800
Victor KryuchkovBurnasyan Federal Medical and Biophysical Centre, 46 Zhivopisnaya Street, Moscow, 123182, Russia.ORCID https://orcid.org/0000-0001-7882-0410
Ivan GolovanovBurnasyan Federal Medical and Biophysical Centre, 46 Zhivopisnaya Street, Moscow, 123182, Russia.
Natalia GudzenkoNational Research Centre for Radiation Medicine, 53 Yu. Illienka Street, Kyiv, 04050, Ukraine.ORCID https://orcid.org/0000-0003-2987-2382
Elizabeth K CahoonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.ORCID https://orcid.org/0000-0002-8028-0588
Paul AlbertDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
Vladimir DrozdovitchDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.ORCID https://orcid.org/0000-0002-7952-379X
Mark P LittleDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.ORCID https://orcid.org/0000-0003-0980-7567
Kiyohiko MabuchiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.ORCID https://orcid.org/0000-0002-8867-8777
Chip StewartBroad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.ORCID https://orcid.org/0000-0003-2245-9552
Gad GetzBroad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.ORCID https://orcid.org/0000-0002-0936-0753
Dimitry BazykaNational Research Centre for Radiation Medicine, 53 Yu. Illienka Street, Kyiv, 04050, Ukraine.ORCID https://orcid.org/0000-0001-9982-5990
Amy Berrington de GonzalezDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.ORCID https://orcid.org/0000-0002-7332-8387
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA. chanocks@mail.nih.gov yeagerm@mail.nih.gov.ORCID https://orcid.org/0000-0002-2324-3393
National Cancer Institute · USFrederick National Laboratory for Cancer Research · USNational Academy of Medical Sciences of Ukraine · UABroad Institute · USState Scientific Center of the Russian Federation - Federal Medical Biophysical Center named after A.I. Burnazyan · RUAmerican Museum of Natural History · USRadiation Effects Research Foundation · JPSymbiosis International University · INUniversidade de São Paulo · BR
Funding
Strategies to Overcome Immune Resistance in Head and Neck CancersP01CA240239 · NCI · YALE UNIVERSITY · PI PAI, SARA ISABEL · 2019 to 2023
$8.4MNCI NIH HHS P01 CA240239
Abstract
Effects of radiation exposure from the Chernobyl nuclear accident remain a topic of interest. We investigated germline de novo mutations (DNMs) in children born to parents employed as cleanup workers or exposed to occupational and environmental ionizing radiation after the accident. Whole-genome sequencing of 130 children (born 1987-2002) and their parents did not reveal an increase in the rates, distributions, or types of DNMs relative to the results of previous studies. We find no elevation in total DNMs, regardless of cumulative preconception gonadal paternal [mean = 365 milligrays (mGy), range = 0 to 4080 mGy] or maternal (mean = 19 mGy, range = 0 to 550 mGy) exposure to ionizing radiation. Thus, we conclude that, over this exposure range, evidence is lacking for a substantial effect on germline DNMs in humans, suggesting minimal impact from transgenerational genetic effects.
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