Evidence map›Paper›PMID 33888590›Full record

ArticleJournal of clinical microbiology2021

A Look Inside: Oral Sampling for Detection of Non-oral Infectious Diseases.

Ethan D Valinetz, Gerard A Cangelosi

Abstract read
In one paragraph

Article in Journal of clinical microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  13. Tongue swab testing on two automated tuberculosis diagnostic platforms, Cepheid XpertmedRxiv : the preprint server for health sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ethan D ValinetzDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Gerard A CangelosiDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-0006-6520

Funding

The Center for Innovation in Point-of-Care Technologies for HIV/AIDS atNorthwestern University (C-THAN) Supplemental RequestU54EB027049 · NIBIB · NORTHWESTERN UNIVERSITY · PI Chad J Achenbach, SALLY Maureen MCFALL · 2018 to 2026
$24.0M
HOST DEFENSE TRAINING IN ALLERGY AND INFECTIOUS DISEASEST32AI007044 · NIAID · UNIVERSITY OF WASHINGTON · PI DAVID Neal FREDRICKS · 1985 to 2026
$14.6M
Non-invasive diagnosis of adult pulmonary tuberculosisR01AI139254 · NIAID · UNIVERSITY OF WASHINGTON · PI CANGELOSI, GERARD A · 2019 to 2022
$1.3M
NIAID NIH HHS R01 AI139254NIAID NIH HHS T32 AI007044NIBIB NIH HHS U54 EB027049
6 · The paper itself

Abstract

Efforts to control transmissible infectious diseases rely on the ability to screen large populations, ideally in community settings. These efforts can be limited by the requirement for invasive or logistically difficult collection of patient samples, such as blood, urine, stool, sputum, and nasopharyngeal swabs. Oral sampling is an appealing, noninvasive alternative that could greatly facilitate high-throughput sampling in community settings. Oral sampling has been described for the detection of dozens of human pathogens, including pathogens whose primary sites of infection are outside of the oral cavity, such as the respiratory pathogens Mycobacterium tuberculosis and SARS-CoV-2. Oral sampling can demonstrate active infections as well as resolving or previous infections, the latter through the detection of antibodies. Its potential applications are diverse, including improved diagnosis in special populations (e.g., children), population surveillance, and infectious disease screening. In this minireview, we address the use of oral samples for the detection of diseases that primarily manifest outside the oral cavity. Focusing on well-supported examples, we describe applications for such methods and highlight their potential advantages and limitations in medicine, public health, and research.

Indexed as

Communicable DiseasesCOVID-19ChildHumansSARS-CoV-2Specimen HandlingSputumCOVID-19diagnosisEbolaHCVhepatitis C virusHIVhuman immunodeficiency virusmalariaMycobacterium tuberculosisparvoviruspediatric infectious diseasePneumocystisrespiratory diseaserespiratory diseasessalivaSARS-CoV-2screeningswabstuberculosis

Identifiers

PMID33888590
PMCPMC8451410

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.