ArticleProceedings of the National Academy of Sciences of the United States of America2021
Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
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Who cites it
32 citing papers in PubMed, 48 citations in OpenAlex.
- Fast skeletal myosin binding protein-C expression exacerbates dysfunction in heart failure.Basic research in cardiology · 2026Article
- Phenotype-specific muscle proteomic profiling in titinopathies.Acta neuropathologica communications · 2026Article
- Proteomic Signatures of Regeneration: Uncovering Extracellular Matrix-Associated Cues in Goldfish Spinal Cord Repair.The Journal of comparative neurology · 2026Article
- Muscle Diffraction at the Life Science X-ray Scattering Beamline.bioRxiv : the preprint server for biology · 2026Article
- Synovial fluid alpha-2-macroglobulin, gelsolin and lubricin distinguish between osteoarthritic and healthy equine joints.Equine veterinary journal · 2026Article
- Fast Myosin Binding Protein-C Is a Vital Regulator in Young and Aged Fast Skeletal Muscle Homeostasis.Journal of cachexia, sarcopenia and muscle · 2025Article
- A Multiomics Approach to Defining Target-Organ Injury in Youths With Primary Hypertension: The SHIP AHOY Cohort.Journal of the American Heart Association · 2025Article
- Sex-dependent and muscle-specific progression of the MYBPC1 E248K Myotrem myopathy in response to aging.JCI insight · 2025Article
- Integrated single-cell functional-proteomic profiling reveals a shift in myofibre specificity in human nemaline myopathy: A proof-of-principle study.The Journal of physiology · 2025Article
- Hochuekkito accelerates recovery from cisplatin induced-muscle atrophy accompanied by slow-twitch fiber-specific microRNA upregulation in mice.Frontiers in pharmacology · 2025Article
- Single-cell nuclear RNA-sequencing reveals dynamic changes in breast muscle cells during the embryonic development of Ding'an goose.PloS one · 2025Article
- Functional role of myosin-binding protein H in thick filaments of developing vertebrate fast-twitch skeletal muscle.The Journal of general physiology · 2024Article
- Overexpression of enhanced yellow fluorescent protein fused with Channelrhodopsin-2 causes contractile dysfunction in skeletal muscle.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Free essential amino acid feeding improves endurance during resistance training via DRP1-dependent mitochondrial remodelling.Journal of cachexia, sarcopenia and muscle · 2024Article
- Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure.Communications biology · 2024Article
- Article
- Functional role of myosin-binding protein H in thick filaments of developing vertebrate fast-twitch skeletal muscle.bioRxiv : the preprint server for biology · 2024Article
- Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads.Nature communications · 2024Article
- PHF2 regulates sarcomeric gene transcription in myogenesis.PloS one · 2024Article
- Unlocking the Role of sMyBP-C: A Key Player in Skeletal Muscle Development and Growth.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Taejeong SongDivision of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati, OH 45267.ORCID 0000-0001-6648-1263
James W McNamaraDivision of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati, OH 45267.
Weikang MaBiophysics Collaborative Access Team, Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL 60616.ORCID 0000-0001-9535-7114
Maicon Landim-VieiraDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306.ORCID 0000-0002-6696-8888
Kyoung Hwan LeeDivision of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655.ORCID 0000-0003-1423-8952
Lisa A MartinDivision of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati, OH 45267.ORCID 0000-0002-6885-1229
Judith A HeinyDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267.
John N LorenzDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267.ORCID 0000-0003-2161-9833
Roger CraigDivision of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655.ORCID 0000-0002-9707-5409
Jose Renato PintoDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306.
Thomas IrvingBiophysics Collaborative Access Team, Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL 60616.ORCID 0000-0003-4848-3323
Sakthivel SadayappanDivision of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati, OH 45267; sadayasl@ucmail.uc.edu.ORCID 0000-0003-2006-7678
University of Cincinnati · USFlorida State University · USIllinois Institute of Technology · USUniversity of Cincinnati Medical Center · USUniversity of Massachusetts Chan Medical School · US
Funding
Ventricular and Cardiac Fiber Characterization and Integration CoreP01HL059408 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI WARSHAW, DAVID M · 1999 to 2014
$26.4MTime resolved SAXS studies on the RP2/Arl3 complex pp.484-485P41GM103622 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2012 to 2020
$11.9MFast myosin binding protein-C and cardiac contractility in heart failureR01HL105826 · NHLBI · UNIVERSITY OF CINCINNATI · PI SADAYAPPAN, SAKTHIVEL · 2011 to 2025
$4.5MMechanism of regulation of cardiac contraction by phosphorylation of myosin binding protein CR01HL139883 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI CRAIG, ROGER W, RALPHE, JOHN CARTER · 2018 to 2021
$2.7MSkeletal Myosin-Binding Protein C (MyBP-C): Molecular Structure and FunctionR01AR067279 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CRAIG, ROGER W, WARSHAW, DAVID M · 2015 to 2019
$2.3MStructure of The Interacting-Heads Motif in Myosin Filaments and MoleculesR01AR072036 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CRAIG, ROGER W · 2017 to 2021
$2.1MMurine 3D Engineered Tissue Model of Human MYBPC3 MutationsR01HL107367 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI RALPHE, JOHN CARTER · 2011 to 2015
$1.8MSlow myosin binding protein-C in skeletal muscle physiologyR01AR078001 · NIAMS · UNIVERSITY OF CINCINNATI · PI SADAYAPPAN, SAKTHIVEL · 2020 to 2023
$1.8MIGF-2R is a new therapeutic target for cardiac ischemia-reperfusion injuryR01HL143490 · NHLBI · UNIVERSITY OF CINCINNATI · PI WANG, YIGANG · 2019 to 2022
$1.6MMolecular mechanism of hypertrophic cardiomyopathy in populations of South Asian descendantsR01HL130356 · NHLBI · UNIVERSITY OF CINCINNATI · PI SADAYAPPAN, SAKTHIVEL · 2016 to 2019
$1.6MNHLBI NIH HHS P01 HL059408NHLBI NIH HHS R01 HL105826NHLBI NIH HHS R01 HL107367NHLBI NIH HHS R01 HL130356NHLBI NIH HHS R01 HL139883NHLBI NIH HHS R01 HL143490NIAMS NIH HHS R01 AR067279NIAMS NIH HHS R01 AR072036NIAMS NIH HHS R01 AR078001NIGMS NIH HHS P41 GM103622
Abstract
Fast skeletal myosin-binding protein-C (fMyBP-C) is one of three MyBP-C paralogs and is predominantly expressed in fast skeletal muscle. Mutations in the gene that encodes fMyBP-C,
Indexed as
Actin CytoskeletonActinsAnimalsCalciumCarrier ProteinsIsometric ContractionMiceMuscle ContractionMuscle Fibers, Fast-TwitchMuscle, SkeletalMuscle StrengthMyofibrilsMyosin Binding Protein CMyosinsSarcomeresActinsCalciumCarrier ProteinsMyosin Binding Protein CMyosinscontractiondistal arthrogryposisfMyBP-CMYBPC2skeletal muscle
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.