Evidence map›Paper›PMID 33888571›Full record

ArticleThorax2021

Novel recessive locus for body mass index in childhood asthma.

Sanghun Lee, Jessica Lasky-Su, Sungho Won, Cecelia Laurie, Juan Carlos Celedón, Christoph Lange, Scott Weiss, Julian Hecker

Open access · greenAbstract read
In one paragraph

Article in Thorax, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Sanghun LeeDepartment of Medical Consilience, Division of Medicine, Graduate School, Dankook University-Jukjeon Campus, Yongin, South Korea shlee92@dankook.ac.kr.
Jessica Lasky-SuChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Sungho WonDepartment of Public Health Science, Seoul National University, Gwanak-gu, South Korea.
Cecelia LaurieDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Juan Carlos CeledónDivision of Pediatric Pulmonary Medicine, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA.
Christoph LangeDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Scott WeissChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Julian HeckerChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Brigham and Women's Hospital · USChildren's Hospital of Pittsburgh · USDankook University · KRHarvard University · USSeoul National University · KRUniversity of Washington · US

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
The Genetic Epidemiology of Asthma in Costa RicaR37HL066289 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2007 to 2015
$14.6M
Finding Genomic Profiles of COVID-19 Phenotypes from the EHRU01HG008685 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIZABETH W KARLSON, Matthew S Lebo · 2015 to 2026
$13.6M
Systems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2016 to 2020
$12.6M
Physics of collective cellular migration in lung health and diseaseP01HL120839 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J · 2014 to 2018
$12.2M
Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Integrative Metabolomics of Asthma SeverityR01HL123915 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LASKY-SU, JESSICA A · 2014 to 2023
$7.0M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
Mechanistic insights into asthma pathogenesis through the integration of asthma genes, risk exposures, and metabolomicsR01HL141826 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LASKY-SU, JESSICA A · 2018 to 2021
$3.4M
Preparing Association Analysis Software Tools for Next Generation Sequencing DataR01HG008976 · NHGRI · HARVARD SCHOOL OF PUBLIC HEALTH · PI LANGE, CHRISTOPH · 2016 to 2018
$1.1M
NHGRI NIH HHS R01 HG008976NHGRI NIH HHS U01 HG008685NHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS P01 HL120839NHLBI NIH HHS P01 HL132825NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL123915NHLBI NIH HHS R01 HL141826NHLBI NIH HHS R37 HL066289NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01 HL120393NIEHS NIH HHS HHSN268201600032C
6 · The paper itself

Abstract

Most genome-wide association studies of obesity and body mass index (BMI) have so far assumed an additive mode of inheritance in their analysis, although association testing supports a recessive effect for some of the established loci, for example, rs1421085 in

Indexed as

AsthmaGenome-Wide Association StudyAlpha-Ketoglutarate-Dependent Dioxygenase FTOBody Mass IndexChildGenetic Predisposition to DiseaseHumansPolymorphism, Single NucleotideAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanasthma geneticspaediatric asthma

Identifiers

PMID33888571
PMCPMC8531156
OpenAlexW3153650975

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.