Evidence map›Paper›PMID 33888450›Full record

ArticleAJNR. American journal of neuroradiology2021

Cerebral Venous Thrombosis in COVID-19: A New York Metropolitan Cohort Study.

F Al-Mufti, K Amuluru, R Sahni, K Bekelis, R Karimi, J Ogulnick, J Cooper, P Overby, R Nuoman, A Tiwari and 14 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. A review of neuro-ophthalmic sequelae following COVID-19 infection and vaccination.Frontiers in cellular and infection microbiology · 2024
    Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Therapeutic Approaches to the Neurologic Manifestations of COVID-19.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. The Hospitalization Rate of Cerebral Venous Sinus Thrombosis before and during COVID-19 Pandemic Era: A Single-Center Retrospective Cohort Study.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 10 institutions in 1 country.

F Al-MuftiFrom the Departments of Neurosurgery (F.A.-M., R.S., J.C., P.O., R.N., J.F.D., T.S., E.G., S.A.M., C.G.) Fawaz.Al-Mufti@wmchealth.org.ORCID 0000-0003-4461-7005
K AmuluruDepartment of Radiology (K.A.), Goodman Campbell Brain and Spine, Indianapolis, Indiana.ORCID 0000-0002-8859-8574
R SahniFrom the Departments of Neurosurgery (F.A.-M., R.S., J.C., P.O., R.N., J.F.D., T.S., E.G., S.A.M., C.G.).ORCID 0000-0003-0836-6501
K BekelisDepartment of Neurosurgery (K. Bekelis), Catholic Health Services and Good Samaritan Hospital, West Islip, New York.ORCID 0000-0001-8428-6410
R KarimiDepartment of Neurosurgery (R.K.), Hackensack University Medical Center, Hackensack, New Jersey.ORCID 0000-0003-4008-204X
J OgulnickNeurology (F.A.-M., R.S., J.O., H.K., K.D., E.G., S.A.M., C.G.), Westchester Medical Center at New York Medical College, Valhalla, New York.ORCID 0000-0002-3657-7894
J CooperFrom the Departments of Neurosurgery (F.A.-M., R.S., J.C., P.O., R.N., J.F.D., T.S., E.G., S.A.M., C.G.).ORCID 0000-0003-4737-3026
P OverbyFrom the Departments of Neurosurgery (F.A.-M., R.S., J.C., P.O., R.N., J.F.D., T.S., E.G., S.A.M., C.G.).ORCID 0000-0002-8303-995X
R NuomanFrom the Departments of Neurosurgery (F.A.-M., R.S., J.C., P.O., R.N., J.F.D., T.S., E.G., S.A.M., C.G.).ORCID 0000-0001-5416-7461
A TiwariDepartment of Neurosurgery (A.T., K. Berekashvili), New York University, New York, New York.ORCID 0000-0001-8595-6631
K BerekashviliDepartment of Neurosurgery (A.T., K. Berekashvili), New York University, New York, New York.ORCID 0000-0002-5861-3323
N DangayachDepartment of Neurosurgery (N.D., J.L.), Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0002-6485-350X
J LiangDepartment of Neurosurgery (N.D., J.L.), Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0001-6055-0918
G GuptaDepartment of Neurological Surgery (G.G., P.K., B.T.), Rutgers University, New Brunswick, New Jersey.ORCID 0000-0002-9442-6007
P KhandelwalDepartment of Neurological Surgery (G.G., P.K., B.T.), Rutgers University, New Brunswick, New Jersey.ORCID 0000-0003-3140-780X
J F DominguezFrom the Departments of Neurosurgery (F.A.-M., R.S., J.C., P.O., R.N., J.F.D., T.S., E.G., S.A.M., C.G.).ORCID 0000-0002-8671-3014
T SursalFrom the Departments of Neurosurgery (F.A.-M., R.S., J.C., P.O., R.N., J.F.D., T.S., E.G., S.A.M., C.G.).ORCID 0000-0002-5342-8137
H KamalNeurology (F.A.-M., R.S., J.O., H.K., K.D., E.G., S.A.M., C.G.), Westchester Medical Center at New York Medical College, Valhalla, New York.ORCID 0000-0002-0852-8278
K DakayNeurology (F.A.-M., R.S., J.O., H.K., K.D., E.G., S.A.M., C.G.), Westchester Medical Center at New York Medical College, Valhalla, New York.ORCID 0000-0001-6903-8013
B TaylorDepartment of Neurological Surgery (G.G., P.K., B.T.), Rutgers University, New Brunswick, New Jersey.ORCID 0000-0001-6111-4747
E GulkoFrom the Departments of Neurosurgery (F.A.-M., R.S., J.C., P.O., R.N., J.F.D., T.S., E.G., S.A.M., C.G.).ORCID 0000-0002-3163-6576
M El-GhanemDepartment of Neurology (M.E.-G.), University of Arizona-Tuscon, Tuscon, Arizona.ORCID 0000-0001-9426-0548
S A MayerFrom the Departments of Neurosurgery (F.A.-M., R.S., J.C., P.O., R.N., J.F.D., T.S., E.G., S.A.M., C.G.).ORCID 0000-0002-1272-6277
C GandhiFrom the Departments of Neurosurgery (F.A.-M., R.S., J.C., P.O., R.N., J.F.D., T.S., E.G., S.A.M., C.G.).ORCID 0000-0002-8423-0414
Westchester Medical Center · USAnna Needs Neuroblastoma Answers · USRutgers, The State University of New Jersey · USIcahn School of Medicine at Mount Sinai · USNew York University · USGood Samaritan University Hospital · USHackensack University Medical Center · USIndiana Spine Group · USUnited States Nuclear Regulatory Commission · USUniversity of Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeSevere Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection is associated with hypercoagulability. We sought to evaluate the demographic and clinical characteristics of cerebral venous thrombosis among patients hospitalized for coronavirus disease 2019 (COVID-19) at 6 tertiary care centers in the New York City metropolitan area. MATERIALS AND

methodsWe conducted a retrospective multicenter cohort study of 13,500 consecutive patients with COVID-19 who were hospitalized between March 1 and May 30, 2020.

resultsOf 13,500 patients with COVID-19, twelve had imaging-proved cerebral venous thrombosis with an incidence of 8.8 per 10,000 during 3 months, which is considerably higher than the reported incidence of cerebral venous thrombosis in the general population of 5 per million annually. There was a male preponderance (8 men, 4 women) and an average age of 49 years (95% CI, 36-62 years; range, 17-95 years). Only 1 patient (8%) had a history of thromboembolic disease. Neurologic symptoms secondary to cerebral venous thrombosis occurred within 24 hours of the onset of the respiratory and constitutional symptoms in 58% of cases, and 75% had venous infarction, hemorrhage, or both on brain imaging. Management consisted of anticoagulation, endovascular thrombectomy, and surgical hematoma evacuation. The mortality rate was 25%.

conclusionsEarly evidence suggests a higher-than-expected frequency of cerebral venous thrombosis among patients hospitalized for COVID-19. Cerebral venous thrombosis should be included in the differential diagnosis of neurologic syndromes associated with SARS-CoV-2 infection.

Indexed as

AdultCausalityCohort StudiesComorbidityCOVID-19FemaleHumansIntracranial ThrombosisMaleMiddle AgedNew York CityRetrospective StudiesRisk FactorsThrombectomyThromboembolismVenous Thrombosis

Identifiers

PMID33888450
PMCPMC8324265
OpenAlexW3155096768

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.