Evidence map›Paper›PMID 33888254›Full record

ReviewJournal of the American College of Cardiology2021

NHLBI-CMREF Workshop Report on Pulmonary Vascular Disease Classification: JACC State-of-the-Art Review.

William M Oldham, Anna R Hemnes, Micheala A Aldred, John Barnard, Evan L Brittain, Stephen Y Chan, Feixiong Cheng, Michael H Cho, Ankit A Desai, Joe G N Garcia and 21 more

Open access · greenAbstract readReview
In one paragraph

Review in Journal of the American College of Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 16 institutions in 2 countries.

William M OldhamDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. Electronic address: woldham@bwh.harvard.edu.
Anna R HemnesVanderbilt University Medical Center, Nashville, Tennessee, USA.
Micheala A AldredIndiana University School of Medicine, Indianapolis, Indiana, USA.
John BarnardLerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Evan L BrittainVanderbilt University Medical Center, Nashville, Tennessee, USA.
Stephen Y ChanCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Division of Cardiology, Department of Medicine, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Feixiong ChengLerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Michael H ChoDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Ankit A DesaiIndiana University School of Medicine, Indianapolis, Indiana, USA.
Joe G N GarciaUniversity of Arizona, Tucson, Arizona, USA.
Mark W GeraciDepartment of Medicine, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Susan D GhiassianScipher Medicine, Inc., Waltham, Massachusetts, USA.
Kathryn T HallDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Evelyn M HornWeill Cornell Medical Center, New York, New York, USA.
Mohit JainUniversity of California at San Diego, San Diego, California, USA.
Rachel S KellyDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Jane A LeopoldDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Sara LindstromUniversity of Washington, Seattle, Washington, USA.
Brian D ModenaNational Jewish Health, Denver, Colorado, USA.
William C NicholsCincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Christopher J RhodesImperial College London, London, United Kingdom.
Wei SunCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Division of Cardiology, Department of Medicine, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Andrew J SweattStanford University School of Medicine, Stanford, California, USA.
Rebecca R VanderpoolDepartment of Medicine, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Martin R WilkinsImperial College London, London, United Kingdom.
Beth WilmotDivision of Geriatrics and Clinical Gerontology, National Institute on Aging and the School of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Roham T ZamanianStanford University School of Medicine, Stanford, California, USA.
Joshua P FesselDivision of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Neil R AggarwalDivision of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Joseph LoscalzoDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Lei XiaoDivision of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: lei.xiao@nih.gov.
Brigham and Women's Hospital · USUniversity of Pittsburgh Medical Center · USCleveland Clinic Lerner College of Medicine · USImperial College London · GBIndiana University School of MedicineNational Institutes of Health · USStanford University · USVanderbilt University Medical Center · USCincinnati Children's Hospital Medical Center · USCornell University · USNational Heart Lung and Blood Institute · USNational Jewish Health · USOregon Health & Science University · USUniversity of Arizona · USUniversity of California San Diego · USUniversity of Washington · US

Funding

SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI George S Watts · 1994 to 2026
$36.7M
The Cellular Response to Elafin in PAHP01HL108797 · NHLBI · STANFORD UNIVERSITY · PI NOLAN, GARRY P · 2011 to 2021
$19.7M
(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9M
Pulmonary Hypertension Breakthrough InitiativeR24HL123767 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ALDRED, MICHEALA A, ERZURUM, SERPIL C. · 2014 to 2017
$10.1M
National Biological Sample and Data Repository for PAHR24HL105333 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI NICHOLS, WILLIAM C · 2012 to 2016
$10.1M
Genetic and Genomic Characterization of the Occurrence and Progression of Interstitial Lung AbnormalitiesR01HL135142 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL H. CHO, GARY MATTHEW HUNNINGHAKE · 2017 to 2026
$7.7M
Genomics of Pulmonary Vascular DiseaseR35HL140019 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI ALDRED, MICHEALA A · 2018 to 2024
$5.6M
Genomic and Circulating Predictors of PAH responseR01HL142720 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Anna R Hemnes · 2019 to 2026
$5.0M
Defining the Complex Biology of the miR-130/301 Family in Pulmonary HypertensionR01HL124021 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHAN, STEPHEN Y · 2014 to 2025
$4.9M
Training Program in Imaging Sciences in Translational Cardiovascular ResearchT32HL129964 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Flordeliza S Villanueva · 2016 to 2026
$4.7M
Novel Involvement of NAMPT and TLR4 in PAH Vascular RemodelingR01HL141387 · NHLBI · UNIVERSITY OF FLORIDA · PI Joe G. N. Garcia, Ayako Makino · 2019 to 2026
$3.8M
Genetic and Functional Dissection of a Cluster of COPD GWAS Signals on Chromosome 4qR01HL147148 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., SILVERMAN, EDWIN K · 2019 to 2022
$3.5M
British Heart Foundation CH/09/001/25945British Heart Foundation FS/15/59/31839British Heart Foundation RE/18/4/34215British Heart Foundation SP/18/10/33975NHLBI NIH HHS K01 HL130625NHLBI NIH HHS K01 HL146980NHLBI NIH HHS K08 HL128802NHLBI NIH HHS K23 HL144418NHLBI NIH HHS K23 HL151892NHLBI NIH HHS P01 HL108797NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL124021NHLBI NIH HHS R01 HL135142NHLBI NIH HHS R01 HL136603NHLBI NIH HHS R01 HL137927NHLBI NIH HHS R01 HL138437NHLBI NIH HHS R01 HL141387NHLBI NIH HHS R01 HL142720NHLBI NIH HHS R01 HL146588NHLBI NIH HHS R01 HL147148NHLBI NIH HHS R24 HL105333NHLBI NIH HHS R24 HL123767NHLBI NIH HHS R35 HL140019NHLBI NIH HHS T32 HL129964NHLBI NIH HHS U01 HL125215NIEHS NIH HHS P30 ES006694
6 · The paper itself

Abstract

The National Heart, Lung, and Blood Institute and the Cardiovascular Medical Research and Education Fund held a workshop on the application of pulmonary vascular disease omics data to the understanding, prevention, and treatment of pulmonary vascular disease. Experts in pulmonary vascular disease, omics, and data analytics met to identify knowledge gaps and formulate ideas for future research priorities in pulmonary vascular disease in line with National Heart, Lung, and Blood Institute Strategic Vision goals. The group identified opportunities to develop analytic approaches to multiomic datasets, to identify molecular pathways in pulmonary vascular disease pathobiology, and to link novel phenotypes to meaningful clinical outcomes. The committee suggested support for interdisciplinary research teams to develop and validate analytic methods, a national effort to coordinate biosamples and data, a consortium of preclinical investigators to expedite target evaluation and drug development, longitudinal assessment of molecular biomarkers in clinical trials, and a task force to develop a master clinical trials protocol for pulmonary vascular disease.

Indexed as

Biomedical ResearchCardiovascular DiseasesComputational BiologyEducationHumansLung DiseasesNational Heart, Lung, and Blood Institute (U.S.)Pulmonary CirculationResearch ReportReview Literature as TopicUnited StatesVascular Diseasesdrug repurposingintegrative omicsmaster clinical trial protocolprecision medicinepulmonary hypertensionsystems biology

Identifiers

PMID33888254
PMCPMC8065203
OpenAlexW3155246825

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.