Evidence map›Paper›PMID 33888083›Full record

ArticleBMC nephrology2021

Renal outcomes of idiopathic and atypical membranous nephropathy in adult Chinese patients: a single center retrospective cohort study.

Zhenbin Jiang, Meishun Cai, Bao Dong, Yu Yan, Yina Wang, Xin Li, Chunying Shao, Li Zuo

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhenbin JiangDepartment of Nephrology, Peking University People's Hospital, 11 Xizhimennan Street, Xicheng District, 100044, Beijing, China.
Meishun CaiDepartment of Nephrology, Peking University People's Hospital, 11 Xizhimennan Street, Xicheng District, 100044, Beijing, China. cai_meishun@163.com.
Bao DongDepartment of Nephrology, Peking University People's Hospital, 11 Xizhimennan Street, Xicheng District, 100044, Beijing, China.
Yu YanDepartment of Nephrology, Peking University People's Hospital, 11 Xizhimennan Street, Xicheng District, 100044, Beijing, China.
Yina WangDepartment of Nephrology, Peking University People's Hospital, 11 Xizhimennan Street, Xicheng District, 100044, Beijing, China.
Xin LiDepartment of Nephrology, Peking University People's Hospital, 11 Xizhimennan Street, Xicheng District, 100044, Beijing, China.
Chunying ShaoDepartment of Nephrology, Peking University People's Hospital, 11 Xizhimennan Street, Xicheng District, 100044, Beijing, China.
Li ZuoDepartment of Nephrology, Peking University People's Hospital, 11 Xizhimennan Street, Xicheng District, 100044, Beijing, China. ZuoLi@bjmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMembranous nephropathy (MN) is mainly classified into idiopathic MN (iMN) and secondary MN in etiology. In recent years, a new kind of membranous nephropathy, atypical membranous nephropathy (aMN) which shows "full house" in immunofluorescence but without definite etiology was paid more attention. In a single center cohort, the renal outcomes of iMN and aMN were compared.

methodsiMN and aMN patients were selected from renal pathology databank from January 2006 to December 2015. Patients' demographics, laboratory values, induction regimens and patients' responses were recorded. Specially, creatinine, eGFR, albumin and 24 h urinary protein excretion were recorded at 6th month after the induction of immunosuppressive (IS) treatment and at the end of follow up. Complete proteinuria remission was defined as urinary protein < 0.3 g/d, partial proteinuria remission was defined as urinary protein between 0.3 g/d ~ 3.5 g/d and decreased > 50 % from the baseline. The primary outcome was worsening renal function, defined as a 30 % or more decrease in eGFR or end-stage renal disease (eGFR < 15ml/min/1.73m

resultsThere were 298 patients diagnosed with MN and followed in our center for 1 year or more, including 145 iMN patients with an average follow-up time of 4.5 ± 2.6 years, and 153 aMN patients with 4.1 ± 2.0 years (p = 0.109). The average age of iMN patients was older than aMN patients (56.1 ± 12.2 versus 47.2 ± 16.2 years old, p < 0.001). There were 99 iMN patients and 105 aMN patients with nephrotic range proteinuria and without previous immunosuppressive treatment. 93 (93.9 %) and 95 (90.5 %) patients underwent immunosuppressive treatment in iMN and aMN group, and there was no significant difference of the overall proteinuria remission rates at 6th month (59.1 % vs. 52.0 %, p = 0.334) and endpoint (73.7 % vs. 69.5 %, p = 0.505) between the two groups. 25 (25.3 %) patients in iMN group and 21 (20.0 %) patients in aMN group reached primary endpoint (X

conclusionsThe proteinuria remission rates and renal outcomes were similar in iMN and aMN patients after covariables were adjusted.

Indexed as

AlbuminuriaAsian PeopleCreatinineDisease ProgressionFemaleFollow-Up StudiesGlomerular Filtration RateGlomerulonephritis, MembranousHumansImmunosuppressive AgentsMaleMiddle AgedProportional Hazards ModelsRemission InductionRetrospective StudiesRisk FactorsCreatinineImmunosuppressive AgentsSerum AlbuminAtypical membranous nephropathyIdiopathic membranous nephropathyWorsening renal function

Identifiers

PMID33888083
PMCPMC8063350

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.