SynthesisTherapeutic advances in respiratory disease
The efficacy and tolerance of prone positioning in non-intubation patients with acute hypoxemic respiratory failure and ARDS: a meta-analysis.
Synthesis in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05178212 (Characteristics and Outcomes of Patients With COVID-19-related Acute Respiratory Failure Treated With High-flow Nasal Oxygen and Awake-prone Position), which is not on this map. Cited by 21 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characteristics and Outcomes of Patients With COVID-19-related Acute Respiratory Failure Treated With High-flow Nasal Oxygen and Awake-prone Position
Who cites it
21 citing papers in PubMed, 6 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Pooled it
- Guideline on positioning and early mobilisation in the critically ill by an expert panel.Intensive care medicine · 2024Guideline
- Prone positioning effect on tracheal intubation rate, mortality and oxygenation parameters in awake non-intubated severe COVID-19-induced respiratory failure: a review of reviews.European journal of medical research · 2024Pooled it
- Awake prone positioning for patients with COVID-19-related respiratory failure: a systematic review and meta-analysis.Internal and emergency medicine · 2024Pooled it
- Conscious prone positioning in nonintubated COVID-19 patients with acute respiratory distress syndrome: systematic review and meta-analysis.Critical care science · 2024Pooled it
- Awake prone positioning for patients with COVID-19 pneumonia in intensive care unit: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- Prone positioning in ARDS.Intensive care medicine · 2026Review
- [Effect of awake prone positioning in non-intubated patients with community-acquired pneumonia complicated by hypoxemia].Medecine tropicale et sante internationale · 2025Review
- Evaluating the Effectiveness of Noninvasive Ventilation in Patients With Acute Respiratory Failure Due to Pneumonia.Cureus · 2025Article
- Effectiveness of bundle of care on tolerance of awake-prone positioning in patients with acute respiratory failure. A multicenter observational study.Intensive care medicine · 2025Observational
- A randomised clinical trial of awake prone positioning in COVID-19 suspects with acute hypoxemic respiratory failure.Contemporary clinical trials communications · 2024Article
- Comparison of the effectiveness of awake-prone positioning and high-flow nasal oxygen in patients with COVID-19-related acute respiratory failure between different waves.Critical care science · 2024Article
- Prone Positioning for Patients With COVID-19-Induced Acute Hypoxemic Respiratory Failure: Flipping the Script.Respiratory care · 2023Review
- Article
- Awake Prone Decubitus Positioning in COVID-19 Patients: A Systematic Review and MetaAnalysis.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2023Article
- Early Prone versus Supine Positioning in Moderate to Severe Coronavirus Disease 2019 Patients with Acute Respiratory Distress Syndrome.Oman medical journal · 2023Article
- Prone position: how understanding and clinical application of a technique progress with time.Anesthesiology and perioperative science · 2023Review
- Awake prone positioning for patients with COVID-19-induced acute hypoxemic respiratory failure.Journal of intensive medicine · 2022Review
- Predictor factors for non-invasive mechanical ventilation failure in severe COVID-19 patients in the intensive care unit: a single-center retrospective study.Journal of anesthesia, analgesia and critical care · 2022Article
- Impact of exposure time in awake prone positioning on clinical outcomes of patients with COVID-19-related acute respiratory failure treated with high-flow nasal oxygen: a multicenter cohort study.Critical care (London, England) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThe application of prone positioning with acute hypoxemic respiratory failure (AHRF) or acute respiratory distress syndrome (ARDS) in non-intubation patients is increasing gradually, applying prone positioning for more high-flow nasal oxygen therapy (HFNC) and non-invasive ventilation (NIV) patients. This meta-analysis evaluates the efficacy and tolerance of prone positioning combined with non-invasive respiratory support in patients with AHRF or ARDS.
methodsWe searched randomized controlled trials (RCTs) (prospective or retrospective cohort studies, RCTs and case series) published in
resultsA total of 16 studies fulfilled selection criteria and included 243 patients. The aggregated intubation rate and mortality rate were 33% [95% confidence interval (CI): 0.26-0.42,
conclusionProne positioning could improve the oxygenation and reduce respiratory rate in both COVID-19 patients and non-COVID-19 patients with non-intubated AHRF or ARDS.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.