Evidence map›Paper›PMID 33887959›Full record

ArticlePsychiatric services (Washington, D.C.)2021

Clinical Characteristics, Outcomes, Disposition, and Acute Care of Children and Adolescents Treated for Acetaminophen Toxicity.

Julia Shekunov, Charles P Lewis, Jennifer L Vande Voort, J Michael Bostwick, Magdalena Romanowicz

Open access · greenAbstract read
In one paragraph

Article in Psychiatric services (Washington, D.C.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. The Effects ofPharmaceuticals (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Julia ShekunovDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota (Shekunov, Vande Voort, Bostwick, Romanowicz); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Lewis).
Charles P LewisDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota (Shekunov, Vande Voort, Bostwick, Romanowicz); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Lewis).
Jennifer L Vande VoortDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota (Shekunov, Vande Voort, Bostwick, Romanowicz); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Lewis).
J Michael BostwickDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota (Shekunov, Vande Voort, Bostwick, Romanowicz); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Lewis).
Magdalena RomanowiczDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota (Shekunov, Vande Voort, Bostwick, Romanowicz); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Lewis).
University of Minnesota · USMayo Clinic · US

Funding

Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR33AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2020 to 2022
$2.4M
Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR21AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2018 to 2019
$437k
NIA NIH HHS R21 AG058738NIA NIH HHS R33 AG058738
6 · The paper itself

Abstract

objectiveAcetaminophen is a common cause of intentional and inadvertent overdoses among children and adolescents worldwide. Little is known about characteristics and clinical outcomes of these youths. The primary goal of this naturalistic study was to describe the psychiatric characteristics, medical management, outcomes, and dispositions of children and adolescents evaluated for excessive acetaminophen exposure.

methodsThe Rochester Epidemiology Project database was searched for all patients ages 0-18 treated for excessive acetaminophen exposure in Olmsted County, Minnesota, during a 7-year period (2004-2010). Demographic factors, overdose intentionality, medical and psychiatric treatment, mental health and addiction history, and disposition from the emergency department (ED) were documented.

resultsOf 110 cases of acetaminophen overdose (89 female patients and 21 male patients), 97 (88%) were intentional and 13 (12%) were unintentional. Fifteen patients (14%) were discharged from the ED, and 69 (63%) required admission to a medical unit. Sixty-four (59%) received

conclusionsAmong pediatric patients with acetaminophen overdoses, psychiatric comorbidities and substance use were common. Most received both inpatient medical and psychiatric treatment. Interventions that restrict acetaminophen access are needed for this population, as are suicide risk reduction interventions for delivery in emergency settings.

Indexed as

AcetaminophenDrug OverdoseAdolescentChildChild, PreschoolFemaleHospitalizationHumansInfantInfant, NewbornMaleMinnesotaRetrospective StudiesSuicide, AttemptedAcetaminophenChild psychiatry/generalOverdoses

Identifiers

PMID33887959
PMCPMC9645125
OpenAlexW3154905461

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.