Evidence map›Paper›PMID 33887904›Full record

ArticleJournal of medicinal chemistry2021

Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects.

Maria Gallo, Estefanía Moreno, Sira Defaus, Antonio Ortega-Alvaro, Angel Gonzalez, Patricia Robledo, Marco Cavaco, Vera Neves, Miguel A R B Castanho, Vicent Casadó and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Maria GalloDepartment of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona Biomedical Research Park, 08003 Barcelona, Spain.ORCID 0000-0001-9099-7235
Estefanía MorenoDepartment of Biochemistry and Molecular Biomedicine, Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-2491-5753
Sira DefausDepartment of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona Biomedical Research Park, 08003 Barcelona, Spain.ORCID 0000-0002-3106-458X
Antonio Ortega-AlvaroDepartment of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona Biomedical Research Park, 08003 Barcelona, Spain.
Angel GonzalezLaboratori de Medicina Computacional, Unitat de Bioestadística, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Patricia RobledoIntegrative Pharmacology and Systems Neuroscience, IMIM-Hospital del Mar Research Institute, 08003 Barcelona, Spain.
Marco CavacoInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.ORCID 0000-0002-0938-9038
Vera NevesInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.ORCID 0000-0002-2989-7208
Miguel A R B CastanhoInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.ORCID 0000-0001-7891-7562
Vicent CasadóDepartment of Biochemistry and Molecular Biomedicine, Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-1764-3825
Leonardo PardoLaboratori de Medicina Computacional, Unitat de Bioestadística, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Rafael MaldonadoDepartment of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona Biomedical Research Park, 08003 Barcelona, Spain.
David AndreuDepartment of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona Biomedical Research Park, 08003 Barcelona, Spain.ORCID 0000-0002-6317-6666
Universitat Pompeu Fabra · ESUniversity of Lisbon · PTInstitute for Research in Biomedicine · ESUniversitat Autònoma de Barcelona · ESHospital Del Mar · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The activation of cannabinoid CB

Indexed as

Administration, OralAmino Acid SequenceAnalgesicsAnimalsBehavior, AnimalBinding SitesBlood-Brain BarrierCannabinoidsCannabisDimerizationMiceMice, Inbred ICRMolecular Dynamics SimulationPainPeptidesReceptor, Cannabinoid, CB1AnalgesicsCannabinoidsPeptidesReceptor, Cannabinoid, CB1Receptor, Serotonin, 5-HT2A

Identifiers

PMID33887904
PMCPMC8486167
OpenAlexW3153979958

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.