Evidence map›Paper›PMID 33887821›Full record

ArticleCancer research and treatment2022

Clinical Characteristics and Treatment Outcomes of Childhood Acute Promyelocytic Leukemia in Korea: A Nationwide Multicenter Retrospective Study by Korean Pediatric Oncology Study Group.

Kyung Mi Park, Keon Hee Yoo, Seong Koo Kim, Jae Wook Lee, Nack-Gyun Chung, Hee Young Ju, Hong Hoe Koo, Chuhl Joo Lyu, Seung Min Han, Jung Woo Han and 23 more

Open access · diamondAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer research and treatment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 19 institutions in 1 country.

Kyung Mi ParkDepartment of Pediatrics, Dongnam Institute of Radiological and Medical Sciences, Busan, Korea.
Keon Hee YooDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Seong Koo KimDepartment of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jae Wook LeeDepartment of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Nack-Gyun ChungDepartment of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Hee Young JuDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Hong Hoe KooDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Chuhl Joo LyuDepartment of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
Seung Min HanDepartment of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
Jung Woo HanDepartment of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
Jung Yoon ChoiDepartment of Pediatrics, Seoul National University Cancer Institute, Seoul National University College of Medicine, Seoul, Korea.
Kyung Taek HongDepartment of Pediatrics, Seoul National University Cancer Institute, Seoul National University College of Medicine, Seoul, Korea.
Hyoung Jin KangDepartment of Pediatrics, Seoul National University Cancer Institute, Seoul National University College of Medicine, Seoul, Korea.
Hee Young ShinDepartment of Pediatrics, Seoul National University Cancer Institute, Seoul National University College of Medicine, Seoul, Korea.
Ho Joon ImDivision of Pediatric Hematology and Oncology, Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
Kyung-Nam KohDivision of Pediatric Hematology and Oncology, Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
Hyery KimDivision of Pediatric Hematology and Oncology, Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
Hoon KookDepartment of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University medical school, Gwangju, Korea.
Hee Jo BaekDepartment of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University medical school, Gwangju, Korea.
Bo Ram KimDepartment of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University medical school, Gwangju, Korea.
Eu Jeen YangDepartment of Pediatrics, Pusan National University School of Medicines, Yangsan, Korea.
Jae Young LimDepartment of Pediatrics, Gyeongsang National University College of Medicine, Jinju, Korea.
Eun Sil ParkDepartment of Pediatrics, Gyeongsang National University College of Medicine, Jinju, Korea.
Eun Jin ChoiDepartment of Pediatrics, Daegu Catholic University School of Medicine, Daegu, Korea.
Sang Kyu ParkDepartment of Pediatrics, University of Ulsan School of Medicine, Ulsan, Korea.
Jae Min LeeDepartment of Pediatrics, Yeungnam University College of Medicine, Daegu, Korea.
Ye Jee ShimDepartment of Pediatrics, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.
Ji Yoon KimDepartment of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Korea.
Ji Kyoung ParkDepartment of Pediatrics, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
Seom Gim KongDepartment of Pediatrics, Kosin University of Medicine, Busan, Korea.
Young Bae ChoiDepartments of Pediatrics, Ajou University School of Medicine, Suwon, Korea.
Bin ChoDepartment of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Young Tak LimDepartment of Pediatrics, Pusan National University School of Medicines, Yangsan, Korea.
Seoul National University Hospital · KRCatholic University of Korea · KRSamsung Medical Center · KRYonsei University · KRChonnam National University Hwasun Hospital · KRGyeongsang National University · KRPusan National University · KRUlsan College · KRUniversity of Ulsan · KRAjou University · KRChonnam National University Hospital · KRDaegu Catholic University · KRDongnam Institute of Radiological & Medical Sciences · KRInje University Busan Paik Hospital · KRKeimyung University · KRKosin University · KRKyungpook National University · KRThe Catholic University of Korea Seoul St. Mary's Hospital · KRYeungnam University College

Funding

Korea Childhood Leukemia Foundation
6 · The paper itself

Abstract

purposeAcute promyelocytic leukemia (APL) is a rare disease in children and there are some different characteristics between children and adult. We aimed to evaluate incidence, clinical characteristics and treatment outcomes of pediatric APL in Korea. MATERIALS AND

methodsSeventy-nine pediatric APL patients diagnosed from January 2009 to December 2016 in 16 tertiary medical centers in Korea were reviewed retrospectively.

resultsOf 801 acute myeloid leukemia children, 79 (9.9%) were diagnosed with APL. The median age at diagnosis was 10.6 years (range, 1.3 to 18.0). Male and female ratio was 1:0.93. Thirty patients (38.0%) had white blood cell (WBC) count greater than 10×109/L at diagnosis. All patients received induction therapy consisting of all-trans retinoic acid and chemotherapy. Five patients (6.6%) died during induction chemotherapy and 66 patients (86.8%) achieved complete remission (CR) after induction chemotherapy. The causes of death were three intracranial hemorrhage, one cerebral infarction, and one sepsis. Five patients (7.1%) suffered a relapse during or after maintenance chemotherapy. The estimated 4-year event-free survival and overall survival (OS) rates were 82.1%±4.4%, 89.7%±5.1%, respectively. The 4-year OS was significantly higher in patients with initial WBC < 10×109/L than in those with initial WBC ≥ 10×109/L (p=0.020).

conclusionThis study showed that the CR rates and survival outcomes in Korean pediatric APL patients were relatively good. The initial WBC count was the most important prognostic factor and most causes of death were related to serious bleeding in the early stage of treatment.

Indexed as

AdolescentAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsChildChild, PreschoolDisease-Free SurvivalFemaleHumansInduction ChemotherapyInfantLeukemia, Promyelocytic, AcuteLeukocyte CountMaleProgression-Free SurvivalRemission InductionRepublic of KoreaAntineoplastic AgentsTretinoinAcute promyelocytic leukemiaAll-trans retinoic acidChildhood

Identifiers

PMID33887821
PMCPMC8756110
OpenAlexW3154473055

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.