Evidence map›Paper›PMID 33887796›Full record

ArticleMedical physics2021

Visual Isocenter Position Enhanced Review (VIPER): a Cherenkov imaging-based solution for MR-linac daily QA.

Daniel A Alexander, Petr Bruza, Aris G Rassias, Jacqueline M Andreozzi, Brian W Pogue, Rongxiao Zhang, David J Gladstone

Abstract read
In one paragraph

Article in Medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniel A AlexanderThayer School of Engineering, Dartmouth College, Hanover, NH, USA.ORCID https://orcid.org/0000-0003-3831-7479
Petr BruzaThayer School of Engineering, Dartmouth College, Hanover, NH, USA.ORCID https://orcid.org/0000-0002-6196-5872
Aris G RassiasThayer School of Engineering, Dartmouth College, Hanover, NH, USA.
Jacqueline M AndreozziMoffitt Cancer Center, Tampa, FL, USA.ORCID https://orcid.org/0000-0002-4720-1163
Brian W PogueThayer School of Engineering, Dartmouth College, Hanover, NH, USA.ORCID https://orcid.org/0000-0002-9887-670X
Rongxiao ZhangThayer School of Engineering, Dartmouth College, Hanover, NH, USA.ORCID https://orcid.org/0000-0002-0423-7828
David J GladstoneThayer School of Engineering, Dartmouth College, Hanover, NH, USA.ORCID https://orcid.org/0000-0002-4086-0297

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
DoseRT™ : A Non-Contact Optical Patient and Beam Dosimetry System for Continuous in vivo Radiotherapy VerificationR44CA232879 · NCI · DOSEOPTICS, LLC · PI William Ware · 2018 to 2026
$5.2M
OPTICAL CHERENKOV IMAGING DOSIMETRY IN HUMAN RADIOTHERAPYR01EB023909 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI GLADSTONE, DAVID J., JARVIS, LESLEY A · 2017 to 2024
$4.4M
NCI NIH HHS P30 CA023108NCI NIH HHS R44 CA232879NIBIB NIH HHS R01 EB023909NIH HHS 5P30 CA023108-41NIH HHS R01 EB023909NIH HHS R44 CA232879Norris Cotton Cancer Center
6 · The paper itself

Abstract

purposeThis study demonstrates a robust Cherenkov imaging-based solution to MR-Linac daily QA, including mechanical-imaging-radiation isocenter coincidence verification.

methodsA fully enclosed acrylic cylindrical phantom was designed to be mountable to the existing jig, indexable to the treatment couch. An ABS plastic conical structure was fixed inside the phantom, held in place with 3D-printed spacers, and filled with water allowing for high edge contrast on MR imaging scans. Both a star shot plan and a four-angle sheet beam plan were delivered to the phantom; the former allowed for radiation isocenter localization in the x-z plane (A/P and L/R directions) relative to physical landmarks on the phantom, and the latter allowed for the longitudinal position of the sheet beam to be encoded as a ring of Cherenkov radiation emitted from the phantom, allowing for isocenter localization on the y-axis (S/I directions). A custom software application was developed to perform near-real-time analysis of the data by any clinical user.

resultsCalibration procedures show that linearity between longitudinal position and optical ring diameter is high (R

conclusionThis novel system provided an efficient, MR safe, all-in-one method for acquisition and near-real-time analysis of isocenter coincidence data. This represents a direct measurement of the 3D isocentricity. The combination of this phantom and the custom analysis application makes this solution readily clinically deployable after the longitudinal analysis of performance consistency.

Indexed as

Magnetic Resonance ImagingParticle AcceleratorsCalibrationPhantoms, ImagingSoftwareCherenkovisocenterMR-linacQA

Identifiers

PMID33887796
PMCPMC8273102

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.