Evidence map›Paper›PMID 33887455›Full record

Observational studyInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021

Cutaneous manifestations associated with anosmia, ageusia and enteritis in SARS-CoV-2 infection - A possible pattern? Observational study and review of the literature.

Victoria Birlutiu, Alin Iulian Feiereisz, George Oprinca, Simona Dobritoiu, Maria Rotaru, Rares Mircea Birlutiu, Gabriela Mariana Iancu

Open access · goldAbstract readReviewObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Victoria BirlutiuFaculty of Medicine, Lucian Blaga University of Sibiu, Sibiu, Romania; Infectious Diseases Clinic, Academic Emergency Hospital Sibiu, Sibiu, Romania.
Alin Iulian FeiereiszInternal Medicine Clinic, Academic Emergency Hospital Sibiu, Sibiu, Romania.
George OprincaDepartment of Pathology, Academic Emergency Hospital Sibiu, Sibiu, Romania.
Simona DobritoiuInfectious Diseases Clinic, Academic Emergency Hospital Sibiu, Sibiu, Romania.
Maria RotaruFaculty of Medicine, Lucian Blaga University of Sibiu, Sibiu, Romania; Dermatology Clinic, Academic Emergency Hospital Sibiu, Sibiu, Romania.
Rares Mircea BirlutiuFaculty of Medicine, Lucian Blaga University of Sibiu, Sibiu, Romania; FOISOR Clinical Hospital of Orthopaedics, Traumatology and Osteoarticular TB, Bucharest, Romania. Electronic address: raresmircea@gmail.com.
Gabriela Mariana IancuFaculty of Medicine, Lucian Blaga University of Sibiu, Sibiu, Romania; Dermatology Clinic, Academic Emergency Hospital Sibiu, Sibiu, Romania.
Lucian Blaga University of Sibiu · ROClinical Emergency Hospital Bucharest · ROSpitalul Clinic Judetean de Urgenta Sibiu · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe cutaneous manifestations of coronavirus disease 2019 (COVID-19) have been covered insufficiently in the literature.

methodsThirty-nine patients admitted to the study hospital with confirmed COVID-19 who experienced various skin manifestations during hospitalization or in the convalescence period, were analysed retrospectively.

resultsThirty-nine patients with COVID-19, admitted to the study hospital between 23 March and 12 September 2020, had intra-infectious rash or lesions of cutaneous vasculitis during convalescence. The most common cutaneous manifestations of COVID-19 were erythematous and erythematous papular rash. Twenty-seven of the 39 patients had anosmia (69.2%), 26 patients had ageusia (66.7%), 34 patients had pneumonia (87.2%) and 24 patients had intra-infectious enterocolitis (61.5%). Skin biopsies were rarely performed in these patients. This article reports the results of biopsies performed in two patients, showing histopathological and immunohistochemical changes in erythematous rash and erythema multiforme-like lesions. Both skin biopsies revealed early fibrous remodelling of the dermis, suggesting similarity with changes that occur in the lungs and other tissues in patients with COVID-19.

conclusionsCorrelations between skin lesions and anosmia, ageusia and enteritis in patients with COVID-19 do not seem to be accidental, but are associated with a similar response to ACE2 receptor expression in these tissues.

Indexed as

SARS-CoV-2AgeusiaAnosmiaCOVID-19EnteritisFemaleHumansMaleRetrospective StudiesSkin DiseasesBiopsyCOVID-19Cutaneous manifestationsLesionsSARS-CoV-2 infection

Identifiers

PMID33887455
PMCPMC8054550
OpenAlexW3152662882

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.