Evidence map›Paper›PMID 33887340›Full record

ArticleInternational journal of cardiology2021

Combining diastolic dysfunction and natriuretic peptides to risk stratify patients with heart failure with reduced ejection fraction.

Mauro Gori, Brian Claggett, Michele Senni, Amil M Shah, Ilan Goldenberg, Valentina Kutyifa, Dorit Knappe, Ann-Catherine Pouleur, Scott D Solomon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Mauro GoriCardiovascular Department, Papa Giovanni XXIII Hospital, Piazza OMS, 1 - 24127, Bergamo, Italy; Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address: mgori@asst-pg23.it.
Brian ClaggettCardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Michele SenniCardiovascular Department, Papa Giovanni XXIII Hospital, Piazza OMS, 1 - 24127, Bergamo, Italy.
Amil M ShahCardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Ilan GoldenbergUniversity of Rochester Medical Center, Rochester, NY, USA.
Valentina KutyifaUniversity of Rochester Medical Center, Rochester, NY, USA.
Dorit KnappeDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
Ann-Catherine PouleurCardiovascular Department, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.
Scott D SolomonCardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Brigham and Women's Hospital · USUniversity of Rochester Medical Center · USCliniques Universitaires Saint-Luc · BEOspedale Papa Giovanni XXIII · ITUniversity Medical Center Hamburg-Eppendorf · DE

Funding

Mapping the Progression to HFpEF in the Elderly through Longitudinal Changes in Cardiac FunctionR01HL135008 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Amil M Shah · 2017 to 2026
$11.5M
Mentoring patient-oriented research in deep phenotyping of cardiac function for heart failure preventionK24HL152008 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SHAH, AMIL M · 2020 to 2024
$608k
NHLBI NIH HHS K24 HL152008NHLBI NIH HHS R01 HL135008
6 · The paper itself

Abstract

backgroundDiastolic dysfunction (DD) might help to risk stratify patients with heart failure (HF) with reduced ejection fraction (HFrEF). Nonetheless, HF guidelines/risk scores don't consider DD. We aimed to show the independent prognostic value of DD for nonfatal HF/death in patients with HFrEF on top of natriuretic peptides (NP).

methodsWe analyzed 1155 baseline echocardiograms of the MADIT-CRT study (LVEF≤30%, QRS ≥ 130 ms, NYHA class I/II), classifying DD according to 2016 ASE/EACVI classification.

resultsPatients were 64 ± 11 years-old, 24% females, LVEF was 24 ± 5%, 58% had abnormal BNP (≥100 pg/ml). While 45% had impaired relaxation, 33% had pseudonormal filling, 12% restrictive pattern, 6% indeterminate diastolic function, 4% were not classifiable due to missing data. During a follow-up of 2.1 ± 1.0 years, there were 233 HF/death. Compared to patients without pseudonormal/restrictive filling and with normal NP (23%), patients with pseudonormal/restrictive filling, alone (15%) or combined to elevated NP (30%), were at higher risk of events (respectively p

conclusionsAmong HFrEF patients with mild symptoms, pseudonormal/restrictive filling, either alone or combined with elevated NP, was associated with high risk of events, as opposed to isolated elevation of NP. DD provided incremental risk prediction for death/HF beyond commonly used markers. These data might suggest to integrate DD into HF guidelines/risk scores.

Indexed as

Heart FailureVentricular Dysfunction, LeftAgedDiastoleFemaleHumansMaleMiddle AgedNatriuretic Peptide, BrainNatriuretic PeptidesStroke VolumeNatriuretic Peptide, BrainNatriuretic PeptidesDiastolic dysfunctionHFrEFNatriuretic peptides

Identifiers

PMID33887340
PMCPMC12611559
OpenAlexW3154140411

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.