Evidence map›Paper›PMID 33887310›Full record

ReviewBehavioural brain research2021

Choose your path: Divergent basolateral amygdala efferents differentially mediate incentive motivation, flexibility and decision-making.

Sara E Keefer, Utsav Gyawali, Donna J Calu

Abstract readReview
In one paragraph

Review in Behavioural brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The Organization of Anxiety Symptoms Along the Threat Imminence Continuum.Current topics in behavioral neurosciences · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Modulation of methamphetamine memory reconsolidation by neural projection from basolateral amygdala to nucleus accumbens.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sara E KeeferDepartment of Anatomy and Neurobiology, University of Maryland, School of Medicine, Baltimore, MD, United States.
Utsav GyawaliDepartment of Anatomy and Neurobiology, University of Maryland, School of Medicine, Baltimore, MD, United States; Program in Neuroscience, University of Maryland, School of Medicine, Baltimore, MD, United States.
Donna J CaluDepartment of Anatomy and Neurobiology, University of Maryland, School of Medicine, Baltimore, MD, United States; Program in Neuroscience, University of Maryland, School of Medicine, Baltimore, MD, United States. Electronic address: dcalu@som.umaryland.edu.

Funding

Role of basolateral amygdala projections in mediating individual differences in motivation and flexibilityR01DA043533 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI GOGERDCHI, DONNA CALU · 2017 to 2022
$2.3M
Individual differences in cortical-striatal pathway utilization regulating flexibilityF32DA053772 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI KEEFER, SARA · 2021 to 2023
$185k
NIDA NIH HHS F32 DA053772NIDA NIH HHS R01 DA043533
6 · The paper itself

Abstract

To survive in a complex environment, individuals form associations between environmental stimuli and rewards to organize and optimize reward seeking behaviors. The basolateral amygdala (BLA) uses these learned associations to inform decision-making processes. In this review, we describe functional projections between BLA and its cortical and striatal targets that promote learning and motivational processes central to decision-making. Specifically, we compare and contrast divergent projections from the BLA to the orbitofrontal (OFC) and to the nucleus accumbens (NAc) and examine the roles of these pathways in associative learning, value-guided decision-making, choice behaviors, as well as cue and context-driven drug seeking. Finally, we consider how these projections are involved in disorders of motivation, with a focus on Substance Use Disorder.

Indexed as

AnimalsBasolateral Nuclear ComplexBehavior, AnimalDecision MakingLearningMotivationNucleus AccumbensPrefrontal CortexSubstance-Related DisordersBasolateral amygdalaBehavioral flexibilityDecision-makingIncentive motivationNucleus accumbensOrbitofrontal cortex

Identifiers

PMID33887310
PMCPMC8189324

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.