Evidence map›Paper›PMID 33887269›Full record

ArticleGastrointestinal endoscopy2021

Expert consensus on endoscopic papillectomy using a Delphi process.

Jeska A Fritzsche, Paul Fockens, Marc Barthet, Marco J Bruno, David L Carr-Locke, Guido Costamagna, Gregory A Coté, Pierre H Deprez, Marc Giovannini, Gregory B Haber and 11 more

Open access · hybridAbstract readConsensus Statement
In one paragraph

Article in Gastrointestinal endoscopy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 38 citations in OpenAlex.

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  7. [Follow-up and Management of Recurrent Nonmalignant Ampullary Neoplasms].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 18 institutions in 11 countries.

Jeska A FritzscheDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam Gastroenterology Endocrinology & Metabolism, Amsterdam, the Netherlands.
Paul FockensDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam Gastroenterology Endocrinology & Metabolism, Amsterdam, the Netherlands.
Marc BarthetDepartment of Hepatogastroenterology, Assistance Publique des Hôpitaux de Marseille, Aix-Marseille Université, Hôpital Nord, Marseille, France.
Marco J BrunoDepartment of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
David L Carr-LockeDepartment of Gastroenterology and Hepatology, Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA.
Guido CostamagnaDigestive Endoscopy Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Catholic University, Rome, Italy.
Gregory A CotéDivision of Gastroenterology and Hepatology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Pierre H DeprezDepartment of Hepato-Gastroenterology, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
Marc GiovanniniEndoscopic Unit, Paoli-Calmettes Institute, Marseille Cedex, France.
Gregory B HaberDivison of Gastroenterology and Hepatology, NYU Langone Medical Center, New York University, New York, New York, USA.
Robert H HawesCenter for Interventional Endoscopy, AdventHealth, Orlando, Florida, USA.
Jong Jin HyunDivision of Gastroenterology, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea.
Takao ItoiDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
Eisuke IwasakiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Leena KylänpaäDepartment of Gastrointestinal and General Surgery, Helsinki University Central Hospital, Helsinki, Finland.
Horst NeuhausDepartment of Gastroenterology, Evangelisches Krankenhaus Düsseldorf, Düsseldorf, Germany.
Jeong Youp ParkDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
D Nageshwar ReddyDepartment of Gastroenterology, Asian Institute of Gastroenterology Hospitals, Hyderabad, India.
Arata SakaiDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Michael J BourkeDepartment of Gastroenterology and Hepatology, Westmead Hospital, and Westmead Clinical School, University of Sydney, Sydney, New South Wales, Australia.
Rogier P VoermansDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam Gastroenterology Endocrinology & Metabolism, Amsterdam, the Netherlands.
AdventHealth Orlando · USAgostino Gemelli University Polyclinic · ITAix-Marseille Université · FRAsian Institute of Gastroenterology · INCliniques Universitaires Saint-Luc · BEErasmus MC · NLEvangelisches Krankenhaus Düsseldorf · DEHelsinki University Hospital · FIInstitut Paoli-Calmettes · FRKeio University · JPKobe University · JPKorea University · KRMedical University of South Carolina · USNewYork–Presbyterian Hospital · USNYU Langone Health · USThe University of Sydney · AUTokyo Medical University · JPYonsei University · KR

Funding

Proteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DON C. ROCKEY · 2020 to 2026
$8.8M
South Carolina Cancer Disparities Research Center (SC CADRE)U54CA210962 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI FORD, MARVELLA ELIZABETH, SALLEY, JUDITH · 2017 to 2023
$6.7M
South Carolina Cancer Disparities Research Center (SC CaDRe)U54CA210963 · NCI · SOUTH CAROLINA STATE UNIVERSITY · PI FORD, MARVELLA ELIZABETH, SALLEY, JUDITH · 2017 to 2023
$6.1M
NCI NIH HHS U54 CA210962NCI NIH HHS U54 CA210963NIDDK NIH HHS P30 DK123704
6 · The paper itself

Abstract

BACKGROUND AND

aimsConsensus regarding an optimal algorithm for endoscopic treatment of papillary adenomas has not been established. We aimed to assess the existing degree of consensus among international experts and develop further concordance by means of a Delphi process.

methodsFifty-two international experts in the field of endoscopic papillectomy were invited to participate. Data were collected between August and December 2019 using an online survey platform. Three rounds were conducted. Consensus was defined as ≥70% agreement.

resultsSixteen experts (31%) completed the full process, and consensus was achieved on 47 of the final 79 statements (59%). Diagnostic workup should include at least an upper endoscopy using a duodenoscope (100%) and biopsy sampling (94%). There should be selected use of additional abdominal imaging (75%-81%). Patients with (suspected) papillary malignancy or over 1 cm intraductal extension should be referred for surgical resection (76%). To prevent pancreatitis, rectal nonsteroidal anti-inflammatory drugs should be administered before resection (82%) and a pancreatic stent should be placed (100%). A biliary stent is indicated in case of ongoing bleeding from the papillary region (76%) or concerns for a (micro)perforation after resection (88%). Follow-up should be started 3 to 6 months after initial papillectomy and repeated every 6 to 12 months for at least 5 years (75%).

conclusionsThis is the first step in developing an international consensus-based algorithm for endoscopic management of papillary adenomas. Surprisingly, in many areas consensus could not be achieved. These aspects should be the focus of future studies.

Indexed as

Ampulla of VaterCommon Bile Duct NeoplasmsConsensusDelphi TechniqueEndoscopyHumansTreatment Outcome

Identifiers

PMID33887269
PMCPMC8878358
OpenAlexW3154146889

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.