Evidence map›Paper›PMID 33887229›Full record

ArticleBiophysical journal2021

EPA and DHA differentially modulate membrane elasticity in the presence of cholesterol.

Miranda L Jacobs, Hammad A Faizi, Justin A Peruzzi, Petia M Vlahovska, Neha P Kamat

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
  2. Lipidome of Endemic FishMembranes · 2026
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  4. Nutrients · 2026
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  11. Review
  12. LPCAT3-dependent remodeling of the phospholipids and lipid rafts is essential for vascular proinflammatory signaling and the development of atherosclerosis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  13. Article
  14. Article
  15. Polyunsaturated fatty acids suppress PIEZO ion channel mechanotransduction in articular chondrocytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Effects of APOE4 on omega-3 brain metabolism across the lifespan.Trends in endocrinology and metabolism: TEM · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Miranda L JacobsDepartment of Biomedical Engineering, McCormick School of Engineering and Applied Science, Northwestern University, Evanston, Illinois; Interdisciplinary Biological Sciences Program, McCormick School of Engineering and Applied Science, Northwestern University, Evanston, Illinois.
Hammad A FaiziDepartment of Mechanical Engineering, McCormick School of Engineering and Applied Science, Northwestern University, Evanston, Illinois.
Justin A PeruzziCenter for Synthetic Biology, McCormick School of Engineering and Applied Science, Northwestern University, Evanston, Illinois; Department of Chemical and Biological Engineering, McCormick School of Engineering and Applied Science, Northwestern University, Evanston, Illinois.
Petia M VlahovskaDepartment of Engineering Sciences and Applied Mathematics, McCormick School of Engineering and Applied Science, Northwestern University, Evanston, Illinois.
Neha P KamatDepartment of Biomedical Engineering, McCormick School of Engineering and Applied Science, Northwestern University, Evanston, Illinois; Center for Synthetic Biology, McCormick School of Engineering and Applied Science, Northwestern University, Evanston, Illinois. Electronic address: nkamat@northwestern.edu.
Northwestern University · US

Funding

Molecular Biophysics Training Program at Northwestern UniversityT32GM008382 · NIGMS · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 1990 to 2020
$4.3M
Triple Quadrupole - Ion Trap Hybrid LC/MS/MS SystemS10RR027926 · NCRR · WAYNE STATE UNIVERSITY · PI MADDIPATI, KRISHNARAO · 2010 to 2010
$425k
NCRR NIH HHS S10 RR027926NIGMS NIH HHS T32 GM008382
6 · The paper itself

Abstract

Polyunsaturated fatty acids (PUFAs) modify the activity of a wide range of membrane proteins and are increasingly hypothesized to modulate protein activity by indirectly altering membrane physical properties. Among the various physical properties affected by PUFAs, the membrane area expansion modulus (K

Indexed as

Docosahexaenoic AcidsEicosapentaenoic AcidCholesterolElasticityFatty Acids, UnsaturatedCholesterolDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Unsaturated

Identifiers

PMID33887229
PMCPMC8390804
OpenAlexW3154194163

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.