ArticleBiophysical journal2021
Glass-like characteristics of intracellular motion in human cells.
Article in Biophysical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Macromolecular Crowding, Phase Separation, and Homeostasis in the Orchestration of Bacterial Cellular Functions.Chemical reviews · 2024Review
- Generative models of morphogenesis in developmental biology.Seminars in cell & developmental biology · 2023Review
- Physicochemical homeostasis in bacteria.FEMS microbiology reviews · 2023Article
- Chloroplasts in plant cells show active glassy behavior under low-light conditions.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Perspective: a stirring role for metabolism in cells.Molecular systems biology · 2022Review
- Simultaneous Exposure of Different Nanoparticles Influences Cell Uptake.Pharmaceutics · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The motion in the cytosol of microorganisms such as bacteria and yeast has been observed to undergo a dramatic slowing down upon cell energy depletion. These observations have been interpreted as the motion being "glassy," but whether this notion is useful also for active, motor-protein-driven transport in eukaryotic cells is less clear. Here, we use fluorescence microscopy of beads in human (HeLa) cells to probe the motion of membrane-surrounded structures that are carried along the cytoskeleton by motor proteins. Evaluating several hallmarks of glassy dynamics, we show that at short length scales, the motion is heterogeneous, is nonergodic, is well described by a model for the displacement distribution in glassy systems, and exhibits a decoupling of the exchange and persistence times. Overall, these results suggest that the short length scale behavior of objects that can be transported actively by motor proteins in human cells shares features with the motion in glassy systems.
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Registered trials
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