Evidence map›Paper›PMID 33887183›Full record

ArticleCurrent biology : CB2021

Concerted evolution reveals co-adapted amino acid substitutions in Na

Shabnam Mohammadi, Lu Yang, Arbel Harpak, Santiago Herrera-Álvarez, María Del Pilar Rodríguez-Ordoñez, Julie Peng, Karen Zhang, Jay F Storz, Susanne Dobler, Andrew J Crawford and 1 more

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Evolutionary insights into NaBMC ecology and evolution · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Identification of the NAJournal of chemical ecology · 2023
    Article
  15. Article
  16. Convergent evolution of toxin resistance in animals.Biological reviews of the Cambridge Philosophical Society · 2022
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Shabnam MohammadiSchool of Biological Sciences, University of Nebraska, Lincoln, NE, USA.
Lu YangDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.
Arbel HarpakDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Santiago Herrera-ÁlvarezDepartment of Biological Sciences, Universidad de los Andes, Bogotá 111711, Colombia.
María Del Pilar Rodríguez-OrdoñezDepartment of Biological Sciences, Universidad de los Andes, Bogotá 111711, Colombia.
Julie PengLewis-Sigler Institute, Princeton University, Princeton, NJ, USA.
Karen ZhangDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.
Jay F StorzSchool of Biological Sciences, University of Nebraska, Lincoln, NE, USA.
Susanne DoblerMolecular Evolutionary Biology, Zoological Institute, Universität Hamburg, Hamburg, Germany.
Andrew J CrawfordDepartment of Biological Sciences, Universidad de los Andes, Bogotá 111711, Colombia. Electronic address: andrew@dna.ac.
Peter AndolfattoDepartment of Biological Sciences, Columbia University, New York, NY, USA. Electronic address: pa2543@columbia.edu.
Princeton University · USUniversidad de Los Andes · COColumbia University · USUniversity of Nebraska–Lincoln · USUniversität Hamburg · DE

Funding

Mutational Pleiotropy, Epistasis, and the Adaptive Evolution of Hemoglobin FunctionR01HL087216 · NHLBI · UNIVERSITY OF NEBRASKA LINCOLN · PI STORZ, JAY · 2008 to 2021
$4.5M
Parallel evolution at Na,K-ATPase: a model system for understanding constraints on the evolution of novel protein functions.R01GM115523 · NIGMS · PRINCETON UNIVERSITY · PI ANDOLFATTO, PETER · 2015 to 2024
$2.8M
NHLBI NIH HHS R01 HL087216NIGMS NIH HHS R01 GM115523
6 · The paper itself

Abstract

Although gene duplication is an important source of evolutionary innovation, the functional divergence of duplicates can be opposed by ongoing gene conversion between them. Here, we report on the evolution of a tandem duplication of Na

Indexed as

Adaptation, PhysiologicalAmino Acid SubstitutionEatingEvolution, MolecularPredatory BehaviorAnimalsAnuraBufonidaeGene ConversionGene DuplicationSodium-Potassium-Exchanging ATPaseSodium-Potassium-Exchanging ATPaseATP-alpha subunitcardiotonic steroidsepistasisgene duplicationmolecular evolutionnatural selectionneofunctionalizationnon-allelic gene conversionpotassium ATPasesodiumtoxin resistance

Identifiers

PMID33887183
PMCPMC8281379
OpenAlexW3154219164

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.