Evidence map›Paper›PMID 33887154›Full record

SynthesisJournal of child and adolescent psychopharmacology2021

The Impact of Failed Antidepressant Trials on Outcomes in Children and Adolescents with Anxiety and Depression: A Systematic Review and Meta-Analysis.

Sarah A Mossman, Jeffrey A Mills, John T Walkup, Jeffrey R Strawn

Open access · greenAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of child and adolescent psychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Tools to Address Children's Mental Health.Focus (American Psychiatric Publishing) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sarah A MossmanAnxiety Disorders Research Program, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Jeffrey A MillsDepartment of Economics, Carl H. Lindner College of Business at the University of Cincinnati, Cincinnati, Ohio, USA.
John T WalkupDepartment of Psychiatry and Behavioral Health, Robert and Anne Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Jeffrey R StrawnAnxiety Disorders Research Program, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
University of Cincinnati Medical Center · USLurie Children's Hospital · US

Funding

Improving the Effectiveness and Safety of Escitalopram in Pediatric Anxiety Disorders Using Pharmacogenetically-guided DosingR01HD099775 · NICHD · UNIVERSITY OF CINCINNATI · PI RAMSEY, LAURA B, STRAWN, JEFFREY ROBERT · 2020 to 2024
$2.9M
Estracellular Vesicles as Non-Invasive Predictors of Antidepressant Outcomes in Pediatric AnxietyR01HD098757 · NICHD · UNIVERSITY OF CINCINNATI · PI STRAWN, JEFFREY ROBERT · 2019 to 2024
$2.4M
NICHD NIH HHS R01 HD098757NICHD NIH HHS R01 HD099775
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Placebo EffectAdolescentAntidepressive Agents, Second-GenerationAntidepressive Agents, TricyclicAnxiety DisordersChildDouble-Blind MethodDrug IndustryHumansMajor Depressive DisorderTreatment OutcomeAntidepressive Agents, Second-GenerationAntidepressive Agents, Tricyclicantidepressantdepressionfundingpediatricplacebo response

Identifiers

PMID33887154
PMCPMC9208430
OpenAlexW3153806326

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.