Evidence map›Paper›PMID 33887126›Full record

ArticleAdvanced healthcare materials2021

Simultaneous Delivery of Multiple Antimicrobial Agents by Biphasic Scaffolds for Effective Treatment of Wound Biofilms.

Yajuan Su, Alec McCarthy, Shannon L Wong, Ronald R Hollins, Guangshun Wang, Jingwei Xie

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 51 citations in OpenAlex.

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  13. Triggered release of antimicrobial peptide from microneedle patches for treatment of wound biofilms.Journal of controlled release : official journal of the Controlled Release Society · 2023
    Article
  14. Microneedles forMaterials today. Bio · 2023
    Review
  15. Article
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  19. Advances in the Sensing and Treatment of Wound Biofilms.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2022
    Review
  20. Advances in the Sensing and Treatment of Wound Biofilms.Angewandte Chemie (International ed. in English) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yajuan SuDepartment of Surgery-Transplant and Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Alec McCarthyDepartment of Surgery-Transplant and Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Shannon L WongDepartment of Surgery-Plastic Surgery, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Ronald R HollinsDepartment of Surgery-Plastic Surgery, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Guangshun WangDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Jingwei XieDepartment of Surgery-Transplant and Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.ORCID 0000-0002-8126-1397
University of Nebraska Medical Center · USUniversity of Nebraska–Lincoln · US

Funding

Nanofiber-based Delivery of Combined Immune-modulating Compounds to Minimize Infection and Enhance Wound HealingR01GM123081 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI XIE, JINGWEI · 2017 to 2024
$2.8M
Novel Janus-type Antimicrobial Dressings for the Treatment of Biofilms in Chronic WoundsR01GM138552 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, GUANGSHUN, XIE, JINGWEI · 2020 to 2023
$2.2M
NIGMS NIH HHS R01 GM123081NIGMS NIH HHS R01 GM138552
6 · The paper itself

Abstract

Biofilms pose a major challenge to control wound-associated infections. Due to biofilm impenetrability, traditional antimicrobial agents are often ineffective in combating biofilms. Herein, a biphasic scaffold is reported as an antimicrobial delivery system by integrating nanofiber mats with dissolvable microneedle arrays for the effective treatment of bacterial biofilms. Different combinations of antimicrobial agents, including AgNO

Indexed as

Methicillin-Resistant Staphylococcus aureusWound InfectionAnti-Bacterial AgentsBiofilmsHumansPseudomonas aeruginosaAnti-Bacterial Agentsantimicrobial agentsbiofilmsmicroneedle arraysnanofiber matswounds

Identifiers

PMID33887126
PMCPMC8222186
OpenAlexW3156998740

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.