SynthesisPloS one2021
Vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2: A scoping review.
Synthesis in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Parental experiences with changes in maternity care during the Covid-19 pandemic: A mixed-studies systematic review.Women and birth : journal of the Australian College of Midwives · 2023Pooled it
- SARS-CoV-2 positivity in offspring and timing of mother-to-child transmission: living systematic review and meta-analysis.BMJ (Clinical research ed.) · 2022Pooled it
- Pooled it
- Absence of SARS-CoV-2 in Second-Trimester Amniotic Fluid During the SARS-CoV-2 Virus Pandemic.Women's health reports (New Rochelle, N.Y.) · 2025Article
- Investigating the mode of transmission of COVID-19 through genital secretions, semen, the birth canal, and lactation: A systematic review.Journal of education and health promotion · 2024Article
- COVID-19's Effect in Pregnancy and Vertical Transmission: A Systematic Review.International journal of preventive medicine · 2024Review
- Article
- Serologic evolution and follow-up to IgG antibodies of infants born to mothers with gestational COVID.BMC pregnancy and childbirth · 2023Article
- Vertical transmission and maternal passive immunity post-SARS-CoV-2.Future virology · 2023Review
- Outcomes of Pregnancy in COVID-19-Positive Mothers in a Tertiary Centre.Life (Basel, Switzerland) · 2023Article
- Placental and Doppler ultrasound findings in pregnant women with SARS-CoV-2 infection.AJOG global reports · 2023Article
- Cross-Sectional Survey of Views on COVID-19 and Its Vaccines Among Pregnant Women.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2023Article
- A prospective, longitudinal, case-control study to evaluate the neurodevelopment of children from birth to adolescence exposed to COVID-19 in utero.BMC pediatrics · 2023Article
- Monitoring of Auditory Function in Newborns of Women Infected by SARS-CoV-2 during Pregnancy.Children (Basel, Switzerland) · 2023Article
- Outcome of Newborns with Confirmed or Possible SARS-CoV-2 Vertical Infection-A Scoping Review.Diagnostics (Basel, Switzerland) · 2023Article
- Possible intrauterine transmission of SARS-CoV-2: Ultrasound findings and viral molecular detection in amniotic fluid.Enfermedades infecciosas y microbiologia clinica (English ed.) · 2022Article
- Maternal-Neonatal Outcomes of Obstetric Deliveries Performed in Negative Pressure Isolation Rooms during the COVID-19 Omicron Variant Pandemic in Taiwan: A Retrospective Cohort Study of a Single Institution.Journal of clinical medicine · 2022Article
- Adapting pediatric health care responses to the COVID-19 pandemic in Japan: A clinical perspective.Global health & medicine · 2022Article
- RNA Viruses, Pregnancy and Vaccination: Emerging Lessons from COVID-19 and Ebola Virus Disease.Pathogens (Basel, Switzerland) · 2022Review
- Decidual immune response following COVID-19 during pregnancy varies by timing of maternal SARS-CoV-2 infection.Journal of reproductive immunology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe evidence for vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is not well established. Therefore, the objective of this review is to summarize emerging evidence on the vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2.
methodsWe conducted a systematic search in PubMed, CINAHL, Web of Science, SCOPUS, and CENTRAL. Likewise, a search for preprint publications was conducted using MedRxiv and Research Square. Studies that addressed vertical transmission of SARS-CoV-2 (concept) among pregnant women infected by Covid-19 (population) in any setting (community, hospital, or home) in any country or context were considered for inclusion. Any types of studies or reports published between December 2019 and September 2020 addressing the effects of SARS-CoV-2 on pregnant women and their newborn babies were included. Studies were screened for eligibility against the inclusion criteria for the review by two reviewers.
resultsWe identified 51 studies reporting 336 newborns screened for COVID-19. From the 336 newborns screened for COVID-19, only 15 (4.4%) were positive for throat swab RT-PCR. All neonates with positive throat swab RT-PCR were delivered by cesarean section. Among neonates with throat swab SARS-CoV-2 positive only five (33.3%) had concomitant placenta, amniotic fluid, and cord blood samples tested, of which only one amniotic fluid sample is positive for RT PCR. Five neonates had elevated IgG and IgM but without intrauterine tissue tested. Four neonates had chest imaging suggestive of COVID-19 pneumonia.
conclusionCurrently there is not enough evidence on vertical virologic transmission of COVID-19 infection during the third trimester of pregnancy. Additionally, there is no evidence to support cesarean delivery, abstaining from breast feeding nor mother and infant separation. Further research involving an adequate sample size of breast milk, placenta, amniotic fluid, and cord blood to ascertain the possibility of vertical transmission and breast milk transfer is needed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.