Evidence map›Paper›PMID 33886601›Full record

ArticlePloS one2021

Suitability of IgG responses to multiple Plasmodium falciparum antigens as markers of transmission intensity and pattern.

Eric Kyei-Baafour, Mavis Oppong, Kwadwo Asamoah Kusi, Abena Fremaah Frempong, Belinda Aculley, Fareed K N Arthur, Regis Wendpayangde Tiendrebeogo, Susheel K Singh, Michael Theisen, Margaret Kweku and 3 more

Open access · goldAbstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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  6. Serology reveals micro-differences inFrontiers in parasitology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Eric Kyei-BaafourDepartment of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.ORCID 0000-0001-6423-1885
Mavis OppongDepartment of Epidemiology and Biostatistics, School of Public Health, University of Health and Allied Sciences, Hohoe, Ghana.
Kwadwo Asamoah KusiDepartment of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.ORCID 0000-0001-5483-9985
Abena Fremaah FrempongDepartment of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
Belinda AculleyDepartment of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
Fareed K N ArthurDepartment of Biochemistry and Biotechnology, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Regis Wendpayangde TiendrebeogoCentre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen, and at Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Susheel K SinghCentre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen, and at Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Michael TheisenCentre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen, and at Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Margaret KwekuDepartment of Epidemiology and Biostatistics, School of Public Health, University of Health and Allied Sciences, Hohoe, Ghana.
Bright AduDepartment of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
Lars HviidCentre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen, and at Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Michael Fokuo OforiDepartment of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.ORCID 0000-0003-2341-7514
University of Ghana · GHStatens Serum Institut · DKUniversity of Copenhagen · DKUniversity of Health and Allied Sciences · GHKwame Nkrumah University of Science and Technology · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Detection of antibody reactivity to appropriate, specific parasite antigens may constitute a sensitive and cost-effective alternative to current tools to monitor malaria transmission across different endemicity settings. This study aimed to determine the suitability of IgG responses to a number of P. falciparum antigens as markers of transmission intensity and pattern. Antibody responses to multiple malaria antigens were determined in 905 participants aged 1-12 years from three districts with low (Keta), medium (Hohoe) and high (Krachi) transmission intensity in the Volta region of Ghana. Blood film microscopy slides and dry blood spots (DBS) were obtained for parasitaemia detection and antibody measurement, respectively. Sera were eluted from DBS and levels of IgG specific for 10 malaria antigens determined by a multiplex assay. Results were compared within and among the districts. Total IgG responses to MSPDBL1, MSPDBLLeucine, MSP2-FC27, RAMA, and PfRh2a and PfRh2b were higher in Krachi than in Hohoe and Keta. Seroprevalence of IgG specific for MSPDBLLeucine, RON4, and PfRh2b were also highest in Krachi. Responses to RALP-1, PfRh2a and PfRh2b were associated with patent but asymptomatic parasitaemia in Keta, while responses to MSPDBL1, MSPDBLLeucine, MSP2-FC27, RAMA, Rh2-2030, and PfRh2b were associated with parasite carriage in Hohoe, but not in Krachi. Using ROC analysis, only PfRh2b was found to predict patent, but asymptomatic, parasitaemia in Keta and Hohoe. Antibody breadth correlated positively with age (r = 0.29, p<0.0001) and parasitaemia (β = 3.91; CI = 1.53 to 6.29), and medium to high transmission (p<0.0001). Our findings suggest differences in malaria-specific antibody responses across the three transmission zones and that PfRh2b has potential as a marker of malaria transmission intensity and pattern. This could have implications for malaria control programs and vaccine trials.

Indexed as

Antibodies, ProtozoanAntigens, ProtozoanBiomarkersChildChild, PreschoolCross-Sectional StudiesFemaleGhanaHumansImmunoglobulin GInfantMalaria, FalciparumMalePlasmodium falciparumROC CurveSeroepidemiologic StudiesAntibodies, ProtozoanAntigens, ProtozoanBiomarkersImmunoglobulin G

Identifiers

PMID33886601
PMCPMC8062017
OpenAlexW3155947469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.