Evidence map›Paper›PMID 33886575›Full record

ArticlePloS one2021

What gaps remain in the HIV cascade of care? Results of a population-based survey in Nsanje District, Malawi.

Nolwenn Conan, Cyrus P Paye, Reinaldo Ortuno, Alexander Chijuwa, Brown Chiwandira, Eric Goemaere, Daniela Belen Garone, Rebecca M Coulborn, Menard Chihana, David Maman

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Nolwenn ConanEpicentre, Paris, France.ORCID 0000-0002-7182-4934
Cyrus P PayeEpicentre, Paris, France.
Reinaldo OrtunoMédecins sans Frontières, Blantyre, Malawi.
Alexander ChijuwaMinistry of Health, District Health Officer, Nsanje, Malawi.
Brown ChiwandiraMinistry of Health, Department of HIV & AIDS, Programme Officer (HIV Care, Treatment & Support programme), Lilongwe, Malawi.
Eric GoemaereSouthern Africa Medical Unit, Cape Town, South Africa.
Daniela Belen GaroneMédecins sans Frontières, Blantyre, Malawi.
Rebecca M CoulbornEpicentre, Paris, France.ORCID 0000-0003-0124-5176
Menard ChihanaEpicentre, Paris, France.
David MamanEpicentre, Paris, France.
Blantyre Institute for Community Ophthalmology · MWMinistry of Health · MWHealth & Medical Publishing Group · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe Malawi Ministry of Health (MoH) has been in collaboration with Médecins sans Frontières (MSF) to increase access to quality HIV care through decentralization of antiretroviral therapy (ART) diagnosis and treatment from hospital to clinics in Nsanje District since 2011. A population-based household survey was implemented to provide information on HIV prevalence and cascade of care to inform and prioritize community-based HIV interventions in the district.

methodsA cross-sectional survey was conducted between September 2016 and January 2017. Using two-stage cluster sampling, eligible adult individuals aged ≥15 years living in the selected households were asked to participate. Participants were interviewed and tested for HIV at home. Those tested HIV-positive had their HIV-RNA viral load (VL) measured, regardless of their ART status. All participants tested HIV-positive at the time of the survey were advised to report their HIV test result to the health facility of their choice that MSF was supported in the district. HIV-RNA VL results were made available in this health facility.

resultsAmong 5,315 eligible individuals, 91.1% were included in the survey and accepted an HIV test. The overall prevalence was 12.1% (95% Confidence Interval (CI): 11.2-13.0) and was higher in women than in men: 14.0% versus 9.5%, P<0.001. Overall HIV-positive status awareness was 80.0% (95%CI: 76.4-83.1) and was associated with sex (P<0.05). Linkage to care was 78.0% (95%CI: 74.3-81.2) and participants in care 76.2% (95%CI: 72.4-79.5). ART coverage among participants aware of their HIV-positive status was 95.3% (95%CI: 92.9-96.9) and was not associated with sex (P = 0.55). Viral load suppression among participants on ART was 89.9% (95%CI: 86.6-92.4) and was not statistically different by sex (p = 0.40).

conclusionsDespite encouraging results in HIV testing coverage, cascade of care, and UNAIDS targets in Nsanje District, some gap remains in the first 90, specifically among men and young adults. Enhanced community engagement and new strategies of testing, such as index testing, could be implemented to identify those who are still undiagnosed, particularly men and young adults.

Indexed as

Antiretroviral Therapy, Highly ActiveAdolescentAdultAgedAnti-HIV AgentsCross-Sectional StudiesFemaleHIV InfectionsHIV TestingHumansMalawiMaleMiddle AgedPrevalenceViral LoadYoung AdultAnti-HIV Agents

Identifiers

PMID33886575
PMCPMC8061928
OpenAlexW3153776724

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.