Evidence map›Paper›PMID 33886419›Full record

ArticleCell cycle (Georgetown, Tex.)2021

BZW1 promotes cell proliferation in prostate cancer by regulating TGF-β1/Smad pathway.

Zhenfeng Shi, Chutan Xiao, Tengceng Lin, Jieyin Wu, Ke Li

Open access · greenAbstract read
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Molecular Insights into BZW1 Expression and [Molecular imaging and biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Zhenfeng ShiDepartment of Urology Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
Chutan XiaoDepartment of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Tengceng LinDepartment of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Jieyin WuDepartment of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Ke LiDepartment of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Sun Yat-sen University · CNThe First Affiliated Hospital, Sun Yat-sen University · CNPeople's Hospital of Xinjiang Uygur Autonomous Region · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, basic leucine zipper and the W2 domain-containing protein 1 (BZW1) are reported to be implicated in tumor progression. However, the role of BZW1 in prostate cancer remains unknown. This study is aimed to investigate the expression of BZW1 and its influence on cell proliferation in prostate cancer. Then, the expression levels of BZW1 were measured in 136 cases of prostate cancer and matched adjacent non-cancerous prostate tissues by quantificational real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC). The effect of BZW1 on cell proliferation was further explored. QRT-PCR analysis showed that the mRNA levels of BZW1 in prostate cancer were significantly greater compared with those in matched adjacent non-cancerous prostate tissues (

Indexed as

Signal TransductionAnimalsCell Cycle ProteinsCell Line, TumorCell ProliferationDNA-Binding ProteinsGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateMaleMiceMice, Inbred BALB CMice, NudeMiddle AgedPrognosisProportional Hazards ModelsBZW1 protein, humanCell Cycle ProteinsDNA-Binding ProteinsSmad ProteinsTransforming Growth Factor beta1biomarkerBZW1prognosisprostate cancersurvival

Identifiers

PMID33886419
PMCPMC8168724
OpenAlexW3152846009

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.