Evidence map›Paper›PMID 33886148›Full record

ArticleAngewandte Chemie (International ed. in English)2021

Genetically Engineered Polypeptide Adhesive Coacervates for Surgical Applications.

Jing Sun, Lingling Xiao, Bo Li, Kelu Zhao, Zili Wang, Yu Zhou, Chao Ma, Jingjing Li, Hongjie Zhang, Andreas Herrmann and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
20.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 138 citations in OpenAlex.

  1. Article
  2. Recent advances onFundamental research · 2026
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  12. [Research progress on anti-swelling hydrogels in biomedical field].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024
    Review
  13. Review
  14. Article
  15. Article
  16. Tailoring the Swelling-Shrinkable Behavior of Hydrogels for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  17. Water-assisted strong underwater adhesion via interfacial water removal and self-adaptive gelation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Jing SunDepartment of Chemistry, Tsinghua University, Beijing, 100084, China.
Lingling XiaoState Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Bo LiState Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Kelu ZhaoState Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Zili WangState Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Yu ZhouDWI-Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, 52056, Aachen, Germany.
Chao MaZernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Jingjing LiState Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Hongjie ZhangDepartment of Chemistry, Tsinghua University, Beijing, 100084, China.
Andreas HerrmannZernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Kai LiuDepartment of Chemistry, Tsinghua University, Beijing, 100084, China.ORCID 0000-0003-0878-5191
Chinese Academy of Sciences · CNUniversity of Groningen · NLDWI – Leibniz Institute for Interactive Materials · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adhesive hydrogels have been developed for wound healing applications. However, their adhesive performance is impaired dramatically due to their high swelling on wet tissues. To tackle this challenge, we fabricated a new type of non-swelling protein adhesive for underwater and in vivo applications. In this soft material, the electrostatic complexation between supercharged polypeptides with oppositely charged surfactants containing 3,4-dihydroxylphenylalanine or azobenzene moieties plays an important role for the formation of ultra-strong adhesive coacervates. Remarkably, the adhesion capability is superior to commercial cyanoacrylate when tested in ambient conditions. Moreover, the adhesion is stronger than other reported protein-based adhesives in underwater environment. The ex vivo and in vivo experiments demonstrate the persistent adhesive performance and outstanding behaviors for wound sealing and healing.

Indexed as

Genetic EngineeringBiocompatible MaterialsHumansHydrogelsPeptidesSurface-Active AgentsTissue AdhesivesWound HealingBiocompatible MaterialsHydrogelsPeptidesSurface-Active AgentsTissue Adhesivesbioadhesivescoacervatessupercharged polypeptidessupramolecular interactionswound healing

Identifiers

PMID33886148
PMCPMC8596419
OpenAlexW3190425176

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.