Evidence map›Paper›PMID 33886017›Full record

ReviewTopics in current chemistry (Cham)2021

Insights into SARS-CoV-2: Medicinal Chemistry Approaches to Combat Its Structural and Functional Biology.

Lin-Sheng Zhuo, Ming-Shu Wang, Jing-Fang Yang, Hong-Chuang Xu, Wei Huang, Lu-Qing Shang, Guang-Fu Yang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Topics in current chemistry (Cham), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Optimization of SARS-CoV-2 MInternational journal of molecular sciences · 2025
    Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lin-Sheng Zhuo *Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, People's Republic of China.
Ming-Shu Wang *Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, People's Republic of China.
Jing-Fang YangKey Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, People's Republic of China.
Hong-Chuang XuKey Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, People's Republic of China.
Wei HuangKey Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, People's Republic of China.
Lu-Qing ShangCollege of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350, People's Republic of China. shanglq@nankai.edu.cn.
Guang-Fu YangKey Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, People's Republic of China. gfyang@mail.ccnu.edu.cn.ORCID http://orcid.org/0000-0003-4384-2593

Funding

The China Postdoctoral Science Foundation 2020M672390the Key Research and Development Program of Hubei Province, China 2020BCB042The National Key R&D Program 2017YFD0200501the Science and Technology Program of Wuhan 2019020701011460
6 · The paper itself

Abstract

Coronavirus disease 2019, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still a pandemic around the world. Currently, specific antiviral drugs to control the epidemic remain deficient. Understanding the details of SARS-CoV-2 structural biology is extremely important for development of antiviral agents that will enable regulation of its life cycle. This review focuses on the structural biology and medicinal chemistry of various key proteins (Spike, ACE2, TMPRSS2, RdRp and M

Indexed as

Angiotensin-Converting Enzyme 2Antiviral AgentsCoronavirus M ProteinsCOVID-19COVID-19 Drug TreatmentDrug RepositioningHumansSARS-CoV-2Serine EndopeptidasesSpike Glycoprotein, CoronavirusViral Matrix ProteinsVirus InternalizationACE2 protein, humanAngiotensin-Converting Enzyme 2Antiviral AgentsCoronavirus M Proteinsmembrane protein, SARS-CoV-2Serine EndopeptidasesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2TMPRSS2 protein, humanViral Matrix ProteinsAntiviralCOVID-19Drug discoverySARS-CoV-2Structural biology

Identifiers

PMID33886017
PMCPMC8061463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.