ArticleEsophagus : official journal of the Japan Esophageal Society2021
Saliva secretion is reduced in proton pump inhibitor-responsive non-erosive reflux disease patients.
Article in Esophagus : official journal of the Japan Esophageal Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Impact of Gastroesophageal Reflux Disease on Salivary Flow Rate, pH and Buffer Capacity: A Systematic Review and Meta-Analysis.Journal of oral rehabilitation · 2025Pooled it
- In females, salivary secretion was significantly lower in patients with severe reflux esophagitis than in healthy controls.Esophagus : official journal of the Japan Esophageal Society · 2024Article
- Among females older than 50 years, saliva secretion is significantly lower in non-erosive reflux disease patients than in healthy controls.Esophagus : official journal of the Japan Esophageal Society · 2024Article
- Characteristics of proton pump inhibitor-resistant severe reflux esophagitis and efficacy of vonoprazan in elderly (older than 75 years) and non-elderly groups.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Article
- Differences in salivary secretion and epidermal growth factor concentrations in mild reflux esophagitis and non-erosive reflux disease.Esophagus : official journal of the Japan Esophageal Society · 2023Article
- Saliva secretion is reduced in mild reflux esophagitis patients.Esophagus : official journal of the Japan Esophageal Society · 2022Article
- Determinants of reflux perception in patients with non-erosive reflux disease who have reflux-related symptoms on potassium-competitive acid blocker therapy.Esophagus : official journal of the Japan Esophageal Society · 2022Article
- Gastroesophageal reflux disease and oral symptoms: A two-sample Mendelian randomization study.Frontiers in genetics · 2022Article
- Comparative Study of Salivary pH, Buffer Capacity, and Flow in Patients with and without Gastroesophageal Reflux Disease.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is no consensus on the relationship between saliva secretion and non-erosive reflux disease (NERD). In this study, saliva secretion and salivary epidermal growth factor (EGF) in patients with NERD were examined.
methodsThirty-one PPI-responsive NERD patients and 31 control subjects were recruited for this case-control study. Saliva secretion testing was performed. Saliva secretion was assessed as follows: each patient chewed sugar-free gum for 3 min prior to endoscopy, and the amount and pH of saliva before and after acid loading as an index of the acid-buffering capacity were measured. The salivary EGF concentration was assessed by ELISA.
resultsThe amount of saliva secreted was significantly lower in the NERD group than in the control group, with medians (25th-75th percentile) of 4.0 mL/3 min (2.0-6.0) and 6.0 (3.9-8.0), respectively (p = 0.0131). Salivary pH was significantly lower in the NERD group (7.0 [6.8-7.2]) than in the control group (7.2 [7.0-7.3], p = 0.0100). Salivary pH after acid loading was significantly lower in the NERD group (5.8 [5.4-6.2]) than in the control group (6.3 [6.1-6.5], p = 0.0002). The difference in pH of stimulated saliva after acid loading (1.2 [0.9-1.5], p = 0.0021) was significantly higher in the NERD group than in the control group (0.8 [0.7-1.1]). The salivary EGF concentration was significantly higher in the NERD group (2513.0 pg/mL [1497.5-5005.0] than in the PPI-responsive group (1641.0 [1139.8-2092.0], p = 0.0032).
conclusionStimulated saliva secretion was reduced in PPI-responsive NERD patients.
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