The need for reconsideration of a mechanism of membrane potential generation using Ling's adsorption theory.

Hirohisa Tamagawa, Titus Mulembo, Bernard Delalande

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Article in European biophysics journal : EBJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 authors.

Hirohisa TamagawaDepartment of Mechanical Engineering, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu, Gifu, 501-1193, Japan. tmgwhrhs@gifu-u.ac.jp.ORCID http://orcid.org/0000-0003-0532-8278

Titus MulemboDepartment of Mechanical Engineering, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu, Gifu, 501-1193, Japan.

Bernard Delalande, 280, avenue de la Pierre Dourdant, 38290, La Verpilliere, France.

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6 · The paper itself

Abstract

Membrane theory attributes the mechanism of generation of membrane potential to transmembrane ion transport, and is typified by the Goldman-Hodgkin-Katz equation (GHK eq.). Despite broad acceptance of the GHK eq. in physiology, it seems unable to explain some characteristics of the membrane potential. The long-underrated Ling's adsorption theory (LA theory) is another mechanism for membrane potential generation. The LA theory attributes the generation mechanism of the membrane potential to an ion adsorption-desorption process. Although the LA theory has not been seriously considered up until today, there are no serious defects in it as a membrane potential generation mechanism. In this work, the authors explain problematic facets of membrane theory from the view of the GHK eq. We propose an alternative concept based on the LA theory that addresses problematic issues with membrane theory. Consequently, an ion adsorption-desorption process could be a genuine mechanism of membrane potential generation as predicted by the LA theory.

Indexed as

Models, BiologicalAdsorptionMembrane PotentialsGoldman-Hodgkin-Katz equationIon adsorption-desorption processLing’s adsorption theoryMembrane potentialMembrane theory

Identifiers

PMID33885916

DOI10.1007/s00249-021-01526-4

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