Evidence map›Paper›PMID 33885790›Full record

ArticleNucleic acids research2021

Arena3Dweb: interactive 3D visualization of multilayered networks.

Evangelos Karatzas, Fotis A Baltoumas, Nikolaos A Panayiotou, Reinhard Schneider, Georgios A Pavlopoulos

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
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  4. Visualizing metagenomic and metatranscriptomic data: A comprehensive review.Computational and structural biotechnology journal · 2024
    Review
  5. Article
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  9. Arena3DNAR genomics and bioinformatics · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Evangelos KaratzasInstitute for Fundamental Biomedical Research, BSRC "Alexander Fleming", Vari, Greece.
Fotis A BaltoumasInstitute for Fundamental Biomedical Research, BSRC "Alexander Fleming", Vari, Greece.
Nikolaos A PanayiotouSchool of Mechanical Engineering, Section of Industrial Management and Operational Research, National Technical University of Athens, Zografou, Athens, Greece.
Reinhard SchneiderUniversity of Luxembourg, Luxembourg Centre for Systems Biomedicine, Bioinformatics Core, Esch-sur-Alzette, Luxembourg.ORCID 0000-0002-8278-1618
Georgios A PavlopoulosInstitute for Fundamental Biomedical Research, BSRC "Alexander Fleming", Vari, Greece.ORCID 0000-0002-4577-8276
Alexander Fleming Biomedical Sciences Research Center · GRNational Technical University of Athens · GRUniversity of Luxembourg · LU

Funding

Hellenic Foundation for Research and Innovation 1855-BOLOGNA
6 · The paper itself

Abstract

Efficient integration and visualization of heterogeneous biomedical information in a single view is a key challenge. In this study, we present Arena3Dweb, the first, fully interactive and dependency-free, web application which allows the visualization of multilayered graphs in 3D space. With Arena3Dweb, users can integrate multiple networks in a single view along with their intra- and inter-layer connections. For clearer and more informative views, users can choose between a plethora of layout algorithms and apply them on a set of selected layers either individually or in combination. Users can align networks and highlight node topological features, whereas each layer as well as the whole scene can be translated, rotated and scaled in 3D space. User-selected edge colors can be used to highlight important paths, while node positioning, coloring and resizing can be adjusted on-the-fly. In its current version, Arena3Dweb supports weighted and unweighted undirected graphs and is written in R, Shiny and JavaScript. We demonstrate the functionality of Arena3Dweb using two different use-case scenarios; one regarding drug repurposing for SARS-CoV-2 and one related to GPCR signaling pathways implicated in melanoma. Arena3Dweb is available at http://bib.fleming.gr:3838/Arena3D or http://bib.fleming.gr/Arena3D.

Indexed as

AlgorithmsData VisualizationInternetProtein Interaction MapsSoftwareColorCOVID-19COVID-19 Drug TreatmentDrug RepositioningHumansMelanomaProgramming LanguagesReceptors, EndothelinSARS-CoV-2Signal TransductionReceptors, Endothelin

Identifiers

PMID33885790
PMCPMC8128064
OpenAlexW3154755494

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.