ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2022
Mortality, Falls, and Fracture Risk Are Positively Associated With Frailty: A SIDIAP Cohort Study of 890 000 Patients.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Frailty Is a Risk Factor for Falls in the Older Adults: A Systematic Review and Meta-Analysis.The journal of nutrition, health & aging · 2023Pooled it
- Fall-related factors in older adults by frailty status: A cross-sectional study.Journal of Korean gerontological nursing · 2026Article
- Network Analysis of Food Intake Patterns and Frailty Dimensions in Chinese Older Adults: A National Cross-Sectional Study.Nutrients · 2026Article
- Correlation Between Objectively Measured Spontaneous Physical Activity and Sedentary Behavior With Frailty Syndrome in Older Adults: A Systematic Review and Meta-Analysis of Observational Studies.Journal of aging research · 2026Review
- Pelvic insufficiency fractures in the elderly - what insights has the past year of research brought? A narrative review.Innovative surgical sciences · 2025Review
- Efficacy of Vitamin D Supplementation on the Risk of Falls Among Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Trends and Risk Factors for the Hospitalization of Older Adults Presenting to Emergency Departments After a Bed-Related Fall: A National Database Analysis.Journal of clinical medicine · 2025Article
- Article
- Association Between Muscle Quality Assessed by the 5-Repetition Sit-to-Stand Test and Falls in Community-Dwelling Older Adults in Japan: A Cross-Sectional Study.Geriatrics (Basel, Switzerland) · 2025Article
- Frailty as a predictor of vertebral fractures in osteoporosis: A clinical perspective.Joint diseases and related surgery · 2025Article
- Association between non-insulin-based insulin resistance indicators and frailty progression: a national cohort study and mendelian randomization analysis.Cardiovascular diabetology · 2025Article
- Impact of frailty and prevalent fractures on the long-term prognosis of patients with cirrhosis: a retrospective study.Scientific reports · 2025Article
- Predictive Value of Inflammation Markers for Frailty in Older Patients with CVD.Clinical interventions in aging · 2025Article
- The Associations between Albumin, Globulin, Albumin-to-globulin Ratio, and Frailty in Middle-aged and Older Adults: Evidence from NHANES 2013-2014.Current pharmaceutical design · 2025Article
- Development and validation of PRE-FRA (PREdiction of FRAilty risk in community older adults) frailty prediction model.Frontiers in public health · 2025Article
- Enhanced Nutritional and Functional Recovery in Femur Fracture Patients Post-Surgery: Preliminary Evidence of Muscle-Targeted Nutritional Support in Real-World Practice.Geriatrics (Basel, Switzerland) · 2024Article
- Gabapentinoids and Risk of Hip Fracture.JAMA network open · 2024Article
- Postfracture survival in a population-based study of adults aged ≥66 yr: a call to action at hospital discharge.JBMR plus · 2024Article
- Performance of FRAX in older adults with frailty: the Framingham Heart Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Association of CT-Derived Skeletal Muscle and Adipose Tissue Metrics with Frailty in Older Adults.Academic radiology · 2024Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundFrail subjects are at increased risk of adverse outcomes. We aimed to assess their risk of falls, all-cause mortality, and fractures.
methodWe used a retrospective cohort study using the Sistema d'Informació per al Desenvolupament de l'Investigació en Atenció Primària database (>6 million residents). Subjects aged 75 years and older with ≥1 year of valid data (2007-2015) were included. Follow-up was carried out from (the latest of) the date of cohort entry up to migration, end of the study period or outcome (whichever came first). The eFRAGICAP classified subjects as fit, mild, moderate, or severely frail. Outcomes (10th revision of the International Classification of Diseases) were incident falls, fractures (overall/hip/vertebral), and all-cause mortality during the study period. Statistics: hazard ratios (HRs), 95% CI adjusted (per age, sex, and socioeconomic status), and unadjusted cause-specific Cox models, accounting for competing risk of death (fit group as the reference).
resultsA total of 893 211 subjects were analyzed; 54.4% were classified as fit, 34.0% as mild, 9.9% as moderate, and 1.6% as severely frail. Compared with the fit, frail had an increased risk of falls (adjusted HR [95% CI] of 1.55 [1.52-1.58], 2.74 [2.66-2.84], and 5.94 [5.52-6.40]), all-cause mortality (adjusted HR [95% CI] of 1.36 [1.35-1.37], 2.19 [2.16-2.23], and 4.29 [4.13-4.45]), and fractures (adjusted HR [95% CI] of 1.21 [1.20-1.23], 1.51 [1.47-1.55], and 2.36 [2.20-2.53]) for mild, moderate, and severe frailty, respectively. Severely frail had a high risk of vertebral (HR of 2.49 [1.99-3.11]) and hip fracture (HR [95% CI] of 1.85 [1.50-2.28]). Accounting for competing risk of death did not change results.
conclusionFrail subjects are at increased risk of death, fractures, and falls. The eFRAGICAP tool can easily assess frailty in electronic primary care databases in Spain.
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