Evidence map›Paper›PMID 33885099›Full record

ReviewNanoscale2021

Genetically encoded RNA nanodevices for cellular imaging and regulation.

Qikun Yu, Kewei Ren, Mingxu You

Abstract readReview
In one paragraph

Review in Nanoscale, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Riboswitches, from cognition to transformation.Synthetic and systems biotechnology · 2023
    Review
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Qikun YuDepartment of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA. mingxuyou@chem.umass.edu.
Kewei RenDepartment of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA. mingxuyou@chem.umass.edu.
Mingxu YouDepartment of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA. mingxuyou@chem.umass.edu.ORCID http://orcid.org/0000-0002-5279-2340

Funding

Genetically-encoded fluorescent RNA sensors for measuring transport of antibiotics into the cytoplasm of Gram-negative pathogens and development of efflux pump inhibitorsR01AI136789 · NIAID · HARVARD MEDICAL SCHOOL · PI LORY, STEPHEN · 2018 to 2022
$3.6M
NIAID NIH HHS R01 AI136789
6 · The paper itself

Abstract

Nucleic acid-based nanodevices have been widely used in the fields of biosensing and nanomedicine. Traditionally, the majority of these nanodevices were first constructed in vitro using synthetic DNA or RNA oligonucleotides and then delivered into cells. Nowadays, the emergence of genetically encoded RNA nanodevices has provided a promising alternative approach for intracellular analysis and regulation. These genetically encoded RNA-based nanodevices can be directly transcribed and continuously produced inside living cells. A variety of highly precise and programmable nanodevices have been constructed in this way during the last decade. In this review, we will summarize the recent advances in the design and function of these artificial genetically encoded RNA nanodevices. In particular, we will focus on their applications in regulating cellular gene expression, imaging, logic operation, structural biology, and optogenetics. We believe these versatile RNA-based nanodevices will be broadly used in the near future to probe and program cells and other biological systems.

Indexed as

Nucleic AcidsRNALogicNanomedicineOligonucleotidesNucleic AcidsOligonucleotidesRNA

Identifiers

PMID33885099
PMCPMC8122502

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.