Evidence map›Paper›PMID 33884928›Full record

ArticleIntegrative cancer therapies

Chelidonine Induces Apoptosis via GADD45a-p53 Regulation in Human Pancreatic Cancer Cells.

Hyun-Jin Jang, Jae Ho Yang, Eunmi Hong, Eunbi Jo, Soon Lee, Sanghun Lee, Jong Soon Choi, Hwa Seung Yoo, Hyuno Kang

Open access · goldAbstract read
In one paragraph

Article in Integrative cancer therapies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Plants (Basel, Switzerland) · 2025
    Review
  2. Article
  3. Chelidonine inhibits melanoma cell malignancy by inactivating TLR4/NF-κB and PI3K/AKT signaling pathways.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
    Article
  4. Article
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  6. Review
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  12. Article
  13. Alkaloids inFrontiers in pharmacology · 2024
    Review
  14. The role of EphA7 in different tumors.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Review
  15. Article
  16. Article
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  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Hyun-Jin JangKorea Basic Science Institute, Daejeon, Republic of Korea.
Jae Ho YangDaejeon Korean Medicine Hospital of Daejeon University, Seoul, Republic of Korea.
Eunmi HongKorea Basic Science Institute, Daejeon, Republic of Korea.
Eunbi JoKorea Basic Science Institute, Daejeon, Republic of Korea.
Soon LeeKorea Basic Science Institute, Daejeon, Republic of Korea.
Sanghun LeeKorea Institute of Oriental Medicine, Daejeon, Republic of Korea.
Jong Soon ChoiKorea Basic Science Institute, Daejeon, Republic of Korea.
Hwa Seung YooDaejeon Korean Medicine Hospital of Daejeon University, Seoul, Republic of Korea.
Hyuno KangKorea Basic Science Institute, Daejeon, Republic of Korea.
Korea Basic Science Institute · KRDaejeon University · KRKorea Institute of Oriental Medicine · KRSungkyunkwan University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Pancreatic NeoplasmsTumor Suppressor Protein p53ApoptosisBenzophenanthridinesCell Cycle ProteinsCell Line, TumorCell ProliferationGADD45 ProteinsHumansBenzophenanthridinesCell Cycle ProteinschelidonineGADD45A protein, humanGADD45 ProteinsTumor Suppressor Protein p53apoptosischelidonineGADD45ap53pancreatic cancer

Identifiers

PMID33884928
PMCPMC8077490
OpenAlexW3156929986

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.