Evidence map›Paper›PMID 33884725›Full record

ArticleChembiochem : a European journal of chemical biology2021

β-Amyloid Targeting with Two-Dimensional Covalent Organic Frameworks: Multi-Scale In-Silico Dissection of Nano-Biointerface.

Reza Maleki, Mohammad Khedri, Sima Rezvantalab, Fatemeh Afsharchi, Kiyan Musaie, Sepehr Shafiee, Mohammad-Ali Shahbazi

Open access · hybridAbstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Reza MalekiComputational Biology and Chemistry Group (CBCG), Universal Scientific Education and Research Network (USERN), 19839-63113, Tehran, Iran.
Mohammad KhedriComputational Biology and Chemistry Group (CBCG), Universal Scientific Education and Research Network (USERN), 19839-63113, Tehran, Iran.
Sima RezvantalabRenewable Energies Department, Faculty of Chemical Engineering, Urmia University of Technology, 57166-419, Urmia, Iran.
Fatemeh AfsharchiZanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University of Medical Sciences, 45139-56184, Zanjan, Iran.
Kiyan MusaieZanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University of Medical Sciences, 45139-56184, Zanjan, Iran.
Sepehr ShafieeSchool of Medicine, Shahid Beheshti University of Medical Sciences, 19839-63113, Tehran, Iran.
Mohammad-Ali ShahbaziZanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University of Medical Sciences, 45139-56184, Zanjan, Iran.ORCID 0000-0002-4860-3017
Zanjan University of Medical Sciences · IRUniversal Scientific Education and Research Network · IRShahid Beheshti University of Medical Sciences · IRUrmia University of Technology · IR

Funding

Academy of Finland 317316
6 · The paper itself

Abstract

Cytotoxic aggregation of misfolded β-amyloid (Aβ) proteins is the main culprit suspected to be behind the development of Alzheimer's disease (AD). In this study, Aβ interactions with the novel two-dimensional (2D) covalent organic frameworks (COFs) as therapeutic options for avoiding β-amyloid aggregation have been investigated. The results from multi-scale atomistic simulations suggest that amine-functionalized COFs with a large surface area (more than 1000 m

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBlood-Brain BarrierComputer SimulationDissectionMetal-Organic FrameworksProtein BindingProtein ConformationStructure-Activity RelationshipAmyloid beta-PeptidesMetal-Organic Frameworks2D materialscovalent organic frameworkslzheimer's diseasemolecular simulationβ-amyloid

Identifiers

PMID33884725
PMCPMC8359851
OpenAlexW3152600854

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.