ArticleThe Plant journal : for cell and molecular biology2021
Ferroportin 3 is a dual-targeted mitochondrial/chloroplast iron exporter necessary for iron homeostasis in Arabidopsis.
Article in The Plant journal : for cell and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- A Metal Importer and Exporter Interact Differently in the Chloroplast and Cell Membrane.Membranes · 2026Article
- OsFPN1 functions as an essential metal transporter for Fe homeostasis and Co/Ni tolerance in rice.Plant molecular biology · 2026Article
- Professor Jeeyon Jeong (1977-2024), an insightful scholar and generous mentor.Frontiers in plant science · 2026Article
- Autophagic regulation of ferroportin 1 induces developmental ferroptosis in rice blast.Autophagy · 2025Article
- What Is Similar, What Is Different? Characterization of Mitoferrin-like Proteins fromInternational journal of molecular sciences · 2025Article
- Barriers and carriers for transition metal homeostasis in plants.Plant communications · 2025Review
- Untangling iron threads: A deep dive into plant intracellular pools.Quantitative plant biology · 2025Review
- Double step screening using endogenous marker improves relative gene targeting efficiency in Arabidopsis.Scientific reports · 2024Article
- Investigating the Role of Known Arabidopsis Iron Genes in a Stress Resilient Soybean Line.International journal of molecular sciences · 2024Article
- Ferrostatin-1 specifically targets mitochondrial iron-sulfur clusters and aconitase to improve cardiac function in Sirtuin 3 cardiomyocyte knockout mice.Journal of molecular and cellular cardiology · 2024Article
- Physiological and molecular bases of the nickel toxicity responses in tomato.Stress biology · 2024Article
- The activation of iron deficiency responses of grapevine rootstocks is dependent to the availability of the nitrogen forms.BMC plant biology · 2024Article
- Growth Developmental Defects of Mitochondrial Iron Transporter 1 and 2 Mutants in Arabidopsis in Iron Sufficient Conditions.Plants (Basel, Switzerland) · 2023Article
- Biofortification of common bean (Food and energy security · 2023Review
- Iron uptake of etioplasts is independent from photosynthesis but applies the reduction-based strategy.Frontiers in plant science · 2023Article
- Black sheep, dark horses, and colorful dogs: a review on the current state of the Gene Ontology with respect to iron homeostasis inFrontiers in plant science · 2023Review
- Golgi-Localized OsFPN1 is Involved in Co and Ni Transport and Their Detoxification in Rice.Rice (New York, N.Y.) · 2022Article
- Iron in leaves: chemical forms, signalling, and in-cell distribution.Journal of experimental botany · 2022Review
- Knockout of Tobacco Homologs ofInternational journal of molecular sciences · 2022Article
- Loss of MAR1 Function is a Marker for Co-Selection of CRISPR-Induced Mutations in Plants.Frontiers in genome editing · 2021Article
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Authors and funding
17 authors at 2 institutions in 1 country.
Funding
Abstract
Mitochondria and chloroplasts are organelles with high iron demand that are particularly susceptible to iron-induced oxidative stress. Despite the necessity of strict iron regulation in these organelles, much remains unknown about mitochondrial and chloroplast iron transport in plants. Here, we propose that Arabidopsis ferroportin 3 (FPN3) is an iron exporter that is dual-targeted to mitochondria and chloroplasts. FPN3 is expressed in shoots, regardless of iron conditions, but its transcripts accumulate under iron deficiency in roots. fpn3 mutants cannot grow as well as the wild type under iron-deficient conditions and their shoot iron levels are lower compared with the wild type. Analyses of iron homeostasis gene expression in fpn3 mutants and inductively coupled plasma mass spectrometry (ICP-MS) measurements show that iron levels in the mitochondria and chloroplasts are increased relative to the wild type, consistent with the proposed role of FPN3 as a mitochondrial/plastid iron exporter. In iron-deficient fpn3 mutants, abnormal mitochondrial ultrastructure was observed, whereas chloroplast ultrastructure was not affected, implying that FPN3 plays a critical role in the mitochondria. Overall, our study suggests that FPN3 is essential for optimal iron homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.