Evidence map›Paper›PMID 33884677›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2021

Simultaneous liver kidney allocation policy and the Safety Net: an early examination of utilization and outcomes in the United States.

Peter J Altshuler, Ashesh P Shah, Adam M Frank, Jaime Glorioso, Hien Dang, Osama Shaheen, Keyur Patel, Carlo B Ramirez, Warren R Maley, Adam S Bodzin

Abstract read
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Kidney safety net utilization after liver transplant for acute alcohol-associated hepatitis.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Simultaneous Liver-Kidney Transplantation versus Liver Transplantation in End-Stage Liver Disease Patients with Kidney Dysfunction.European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Peter J AltshulerDepartment of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0002-2993-0012
Ashesh P ShahDepartment of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0001-9286-4161
Adam M FrankDepartment of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
Jaime GloriosoDepartment of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
Hien DangDepartment of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
Osama ShaheenDepartment of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
Keyur PatelDepartment of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
Carlo B RamirezDepartment of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
Warren R MaleyDepartment of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
Adam S BodzinDepartment of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.

Funding

CLINICAL PHARMACOLOGY TRAINING PROGRAMT32GM008562 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI WALTER K KRAFT, Scott A. Waldman · 1995 to 2026
$10.2M
HRSA HHS 234-2005-370011CNational Institutes of Health institutional training T32GM008562NIGMS NIH HHS T32 GM008562
6 · The paper itself

Abstract

Rates of simultaneous liver kidney (SLK) transplantation in the United States have progressively risen. On 8/10/17, the Organ Procurement and Transplantation Network implemented a policy defining criteria for SLK, with a "Safety Net" to prioritize kidney allocation to liver recipients with ongoing renal failure. We performed a retrospective review of the United Network for Organ Sharing (UNOS) database to evaluate policy impact on SLK, kidney after liver (KAL) and kidney transplant alone (KTA). Rates and outcomes of SLK and KAL transplants were compared, as was utilization of high-quality kidney allografts with Kidney Donor Profile Indices (KDPI) <35%. Here, SLK transplants comprised 9.0% and 4.5% of total postpolicy liver and kidney transplants compared to 10.2% and 5.5% prior. Policy enactment did not affect 1-year graft or patient survival for SLK and KAL populations. Less postpolicy SLK transplants utilized high-quality kidney allografts; in all transplant settings, outcomes using high-quality grafts remained stable. These findings suggest that policy implementation has reduced kidney allograft use in SLK transplantation, although both SLK and KAL rates have recently increased. Despite decreased high-quality kidney allograft use, SLK and KAL outcomes have remained stable. Additional studies and long-term follow-up will ensure optimal organ access and sharing.

Indexed as

Tissue and Organ ProcurementGraft SurvivalHumansKidneyLiverPolicyRetrospective StudiesRisk FactorsUnited Statesmultiorganorgan allocationpolicysafety netsimultaneous liver kidney transplantUnited Network for Organ Sharing

Identifiers

PMID33884677
PMCPMC8461480

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.