Evidence map›Paper›PMID 33884574›Full record

ArticleActa parasitologica2021

The Role of Oxidative and Nitrosative Stress of Silver Nanoparticles in Human Parasitic Helminth Brugia malayi: A Mechanistic Insight.

Sneha Hande, Vijay Sonkar, Priyanka Bhoj, Namdev Togre, Kalyan Goswami, Debabrata Dash

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Article in Acta parasitologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sneha HandeDepartment of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, 442 102, India.
Vijay SonkarDepartment of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, Varanasi, 221 005, India.
Priyanka BhojDepartment of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, 442 102, India.
Namdev TogreDepartment of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, 442 102, India.
Kalyan GoswamiDepartment of Biochemistry, All India Institute of Medical Sciences, Kalyani, West Bengal, 741 245, India. goswamikln@gmail.com.ORCID http://orcid.org/0000-0002-5052-0675
Debabrata DashDepartment of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, Varanasi, 221 005, India. ddash.biochem@gmail.com.
Mahatma Gandhi Institute of Medical Sciences · INInstitute of Medical Sciences · INAll India Institute of Medical Sciences · IN

Funding

Department of Biotechnology, BT/PR/4988/INF/22/155/2012
6 · The paper itself

Abstract

purposeSilver nanoparticles (AgNPs) mediated apoptosis is well-known but its rationale is yet to be elucidated. This study explored the mechanistic underpinning of the apoptosis in the Brugia malayi parasitic model.

methodSilver nanoparticles were synthesized and tested against B. malayi microfilariae (Mf) to explore the role of oxidative and nitrosative stress in its apoptotic effect.

resultsAgNPs caused significant decrease in reduced glutathione (GSH) level and increase in both protein carbonylation and nitric oxide (NO) level indicating oxidative as well as nitrosative stress. Both GSH and nitric oxide synthase (NOS) inhibitors exhibited marked reversal. Nanoparticles and NO-donor in combination but not the NO-donor alone showed significant antiparasitic effect implying the requisite of combined oxidative and nitrosative stress to induce apoptosis. Synthetically prepared peroxynitrite from NaNO

conclusionWe conclude that apoptosis by AgNPs is possibly mediated through peroxynitrite dependent depletion of GSH; this provides a significant insight into the pharmacological as well as toxicological impact of AgNPs.

Indexed as

Brugia malayiMetal NanoparticlesAnimalsHydrogen PeroxideNitrosative StressOxidative StressSilverHydrogen PeroxideSilverApoptosisBrugia malayiGlutathioneNitrosative stressOxidative stressSilver nanoparticles

Identifiers

PMID33884574
OpenAlexW3154193378

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.