Evidence map›Paper›PMID 33884564›Full record

ArticleJournal of cardiovascular translational research2021

Design and Rationale of the Swiss-Apero Randomized Clinical Trial: Comparison of Amplatzer Amulet vs Watchman Device in Patients Undergoing Left Atrial Appendage Closure.

Roberto Galea, Federico De Marco, Adel Aminian, Nicolas Meneveau, Frederic Anselme, Christoph Gräni, Adrian T Huber, Emmanuel Teiger, Xavier Iriart, Marco Angelillis and 11 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03399851 (Comparison of Amplatzer Amulet vs Watchman Device in Patients Undergoing Left Atrial Appendage Closure), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03399851 naunknown statusnot on this map

Comparison of Amplatzer Amulet vs Watchman Device in Patients Undergoing Left Atrial Appendage Closure: the SWISS-APERO Randomized Clinical Trial

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2018 to 2026Enrolled200ConditionsLeft Atrial Appendage ClosureArmsAmplatzer Amulet for left atrial appendage closure, Watchman/FLX for left atrial appendage closure
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 11 institutions in 4 countries.

Roberto GaleaDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.
Federico De MarcoDepartment of Cardiology, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Adel AminianDepartment of Cardiology, Centre Hospitalier Universitaire de Charleroi, Charleroi, Belgium.
Nicolas MeneveauBesancon University Hospital, EA3920, University of Burgundy Franche-Comté, Besancon, France.
Frederic AnselmeDepartment of Cardiology, University Hospital of Rouen, Rouen, France.
Christoph GräniDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.
Adrian T HuberDepartment of Diagnostic, Interventional and Pediatric Radiology, Bern University Hospital, University of Bern, Bern, Switzerland.
Emmanuel TeigerDepartment of Cardiology, Henri-Mondor Hospital, Public Assistance Hospitals of Paris, Créteil, France.
Xavier IriartDepartment of Pediatric and Adult Congenital Cardiology, Hôpital Cardiologique du Haut- Lévêque, CHU de Bordeaux, Bordeaux-Pessac, France.
Marco AngelillisCardiac Thoracic and Vascular Department, University of Pisa, Pisa, Italy.
Nicolas BruggerDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.
Alessandro SpiritoDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.
Noé CorpatauxDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.
Anna FranzoneDepartment of Advanced Biomedical Sciences, University Federico II University, Naples, Italy.
Pascal VranckxDepartment of Cardiology and Critical Care Medicine, Hartcentrum Hasselt, Jessa Ziekenhuis, Hasselt, Belgium.
Urs FischerDepartment of Neurology, Bern University Hospital, University of Bern, Bern, Switzerland.
Giovanni PedrazziniCardiocentro Ticino, Via Tesserete 48, 6900, Lugano, Switzerland.
Francesco BedogniDepartment of Cardiology, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Stephan WindeckerDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.
Lorenz RäberDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.
Marco ValgimigliDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland. marco.valgimigli@cardiocentro.org.ORCID 0000-0002-4353-7110
University of Bern · CHIRCCS Policlinico San Donato · ITCentre Hospitalier Universitaire de Bordeaux · FREpatocentro Ticino · CHFederico II University Hospital · ITGrand Charleroi Hospital · BEJessa Hospital · BEUniversité de Bourgogne · FRUniversité de Rouen Normandie · FRUniversity Hospital of Bern · CHUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Residual or newly acquired leaks are routinely appraised after left atrial appendage closure (LAAC). The Watchman and the Amulet are the two most frequently used devices for LAAC but no randomized study has so far assessed their comparative leak rates after intervention. The "Comparison of Amplatzer Amulet vs Watchman devices in patients undergoing left atrial appendage closure" (Swiss-Apero, clinicaltrial.gov NCT03399851) is an academic-sponsored multicenter, randomized clinical trial comparing Amulet versus Watchman/FLX devices among patients undergoing a clinically indicated LAAC. The study is designed to assess the superiority of Amulet vs. Watchman/FLX in terms of leaks detected by cardiac computed tomography angiography (CCTA) at 45 days (primary endpoint) and 13 months (secondary endpoint) after intervention by an imaging Core Laboratory. The Swiss-Apero study is the first randomized clinical trial comparing Amulet and Watchman/FLX with respect to the prevalence of post-procedural leak as assessed with CCTA.

Indexed as

Atrial AppendageAtrial FibrillationCardiac CatheterizationTomography, X-Ray ComputedComputed Tomography AngiographyEuropeHumansMulticenter Studies as TopicRandomized Controlled Trials as TopicResearch DesignTime FactorsTreatment OutcomeAmuletCardiac computed tomography angiographyLeft atrial appendage closureRandomized clinical trialWatchmanWatchman FLX

Identifiers

PMID33884564
OpenAlexW3154465361

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.