Evidence map›Paper›PMID 33884529›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021

Face pareidolia is associated with right striatal dysfunction in drug-naïve patients with Parkinson's disease.

Hidetomo Murakami, Tomotaka Shiraishi, Tadashi Umehara, Shusaku Omoto, Maki Takahashi, Haruhiko Motegi, Takahiro Maku, Takeo Sato, Hiroki Takatsu, Teppei Komatsu and 4 more

Registry-linked trialAbstract read
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05483036 (Perception in Parkinson's Disease), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05483036 completednot on this mapstarted 2022, after this paper: background citation

Perception in Parkinson's Disease

TypeobservationalSponsorBoston University Charles River CampusRan2022 to 2025Enrolled54ConditionsParkinson's Disease, Perception, Visual Hallucination
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Enhanced visual illusions in Parkinson's disease with cardiovascular autonomic failure.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Effects of monotherapy with a monoamine oxidase B inhibitor on motor symptoms in Parkinson's disease are dependent on frontal function.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Hidetomo MurakamiDepartment of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 108-8461, Japan. hidneu@yahoo.co.jp.ORCID http://orcid.org/0000-0002-6551-4622
Tomotaka ShiraishiDepartment of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 108-8461, Japan.
Tadashi UmeharaDepartment of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 108-8461, Japan.
Shusaku OmotoDepartment of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 108-8461, Japan.
Maki TakahashiDepartment of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 108-8461, Japan.
Haruhiko MotegiDepartment of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 108-8461, Japan.
Takahiro MakuDepartment of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 108-8461, Japan.
Takeo SatoDepartment of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 108-8461, Japan.
Hiroki TakatsuDepartment of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 108-8461, Japan.
Teppei KomatsuDepartment of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 108-8461, Japan.
Keiko BonoDepartment of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 108-8461, Japan.
Kenichiro SakaiDepartment of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 108-8461, Japan.
Hidetaka MitsumuraDepartment of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 108-8461, Japan.
Yasuyuki IguchiDepartment of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 108-8461, Japan.
Jikei University School of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimSome patients with Parkinson's disease (PD) present with pareidolia, an illusion of a meaningless stimulus as a familiar object known to the observer. Since the striatum is associated with processing of visual information, we investigated correlations of pareidolia with motor symptoms and striatal dopaminergic function.

methodA noise pareidolia test, assessment of motor symptoms using MDS-UPDRS and

resultsOf the 58 participants, 22 had at least one illusory response. Mean scores for MDS-UPDRS part III (p<0.05), rigidity (p<0.05), and rigidity on the left side of the body (p<0.01) in patients with pareidolia were significantly higher than those in patients without pareidolia. Uptake of

conclusionPareidolia in PD patients is associated with dysfunction in the right striatum.

Indexed as

Parkinson DiseasePharmaceutical PreparationsCorpus StriatumHumansHypokinesiaTomography, Emission-Computed, Single-PhotonPharmaceutical PreparationsBradykinesiaMinor hallucinationPareidoliaParkinson’s diseaseRigidityStriatum

Identifiers

PMID33884529
OpenAlexW3154186572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.