Evidence map›Paper›PMID 33884509›Full record

ArticleBasic research in cardiology2021

Macrophage depletion in stellate ganglia alleviates cardiac sympathetic overactivation and ventricular arrhythmogenesis by attenuating neuroinflammation in heart failure.

Dongze Zhang, Wenfeng Hu, Huiyin Tu, Bryan T Hackfort, Bin Duan, Wanfen Xiong, Michael C Wadman, Yu-Long Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Basic research in cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Dongze Zhang *Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA. dongze.zhang@unmc.edu.
Wenfeng Hu *Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Huiyin Tu *Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Bryan T HackfortDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Bin DuanMary & Dick Holland Regenerative Medicine Program, Division of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Wanfen XiongDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Michael C WadmanDepartment of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Yu-Long LiDepartment of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA. yulongli@unmc.edu.ORCID http://orcid.org/0000-0001-5407-2761
University of Nebraska Medical Center · USNebraska Medical Center · US

Funding

Mechanisms of cardiac sympathetic hyperactivity in chronic heart failureR01HL137832 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Yu-Long Li · 2017 to 2026
$4.1M
Potential therapies to improve ventricular vagal function in type 2 diabetesR01HL144146 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI LI, YU-LONG · 2018 to 2021
$1.5M
Dysfunction of Baroreceptor Neurons in Heart Failure: Cellular and Molecular MechR01HL098503 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI LI, YU-LONG · 2010 to 2013
$1.5M
NHLBI NIH HHS R01 HL098503NHLBI NIH HHS R01 HL137832NHLBI NIH HHS R01 HL144146
6 · The paper itself

Abstract

Cardiac sympathetic overactivation is involved in arrhythmogenesis in patients with chronic heart failure (CHF). Inflammatory infiltration in the stellate ganglion (SG) is a critical factor for cardiac sympathoexcitation in patients with ventricular arrhythmias. This study aims to investigate if macrophage depletion in SGs decreases cardiac sympathetic overactivation and ventricular arrhythmogenesis in CHF. Surgical ligation of the coronary artery was used for induction of CHF. Clodronate liposomes were microinjected into bilateral SGs of CHF rats for macrophage depletion. Using cytokine array, immunofluorescence staining, and Western blot analysis, we found that macrophage expansion and expression of TNFα and IL-1β in SGs were markedly increased in CHF rats. Flow cytometry data confirmed that the percentage of macrophages in SGs was higher in CHF rats than that in sham rats. Clodronate liposomes significantly reduced CHF-elevated proinflammatory cytokine levels and macrophage expansion in SGs. Clodronate liposomes also reduced CHF-increased N-type Ca

Indexed as

Action PotentialsAnimalsAnti-Inflammatory AgentsCalcium Channels, N-TypeCalcium SignalingClodronic AcidDisease Models, AnimalHeartHeart FailureHeart RateInflammation MediatorsInterleukin-1betaLiposomesMacrophagesMaleNeuroinflammatory DiseasesAnti-Inflammatory AgentsCalcium Channels, N-TypeClodronic AcidIL1B protein, ratInflammation MediatorsInterleukin-1betaLiposomesTumor Necrosis Factor-alphaCalcium channelCardiac sympathetic neuronChronic heart failureClodronate liposomesMacrophage depletionVentricular arrhythmia

Identifiers

PMID33884509
PMCPMC8060235
OpenAlexW3154738857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.