ArticleBMJ paediatrics open2021
Incidence of Kawasaki disease before and during the COVID-19 pandemic: a retrospective cohort study in Japan.
Article in BMJ paediatrics open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Association between PMEuropean journal of pediatrics · 2026Article
- Did the COVID-19 pandemic change the Kawasaki disease phenotype? Observations from the International Kawasaki Disease Registry.Pediatric cardiology · 2026Article
- Subgroups of Kawasaki disease in Japanese patients and temporal change: a retrospective data-driven cluster analysis.Clinical rheumatology · 2026Article
- Kawasaki Disease in Canada: The Impact of the COVID-19 Pandemic.CJC pediatric and congenital heart disease · 2025Article
- Epidemiological trends and healthcare burden of Kawasaki disease in children under 5 years in Taiwan.Scientific reports · 2025Article
- Kawasaki disease in the pre- and post-COVID-19 era: shifts in patterns and outcomes from a multi-center study.European journal of pediatrics · 2025Article
- An Update on Multi-System Inflammatory Syndrome in Children.Current rheumatology reports · 2025Review
- An Update on Kawasaki Disease.Current rheumatology reports · 2024Review
- Kawasaki disease before and during the COVID-19 pandemic: a single-center comparative study in Switzerland.BMC pediatrics · 2024Article
- Incidence of Kawasaki disease among children in Chandigarh, India during 2015-2019: a trend analysis.The Lancet regional health. Southeast Asia · 2024Article
- A Comparison of Kawasaki Disease during the SARS-CoV-2 Pandemic with Multisystem Inflammatory Syndrome in Children.Children (Basel, Switzerland) · 2024Article
- Spatiotemporal analysis of the association between Kawasaki disease incidence and PMBMJ paediatrics open · 2024Article
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- New-onset systemic vasculitis following SARS-CoV-2 infection and vaccination: the trigger, phenotype, and outcome.Clinical rheumatology · 2023Review
- SARS-CoV-2 infection in the context of Kawasaki disease and multisystem inflammatory syndrome in children.Medical microbiology and immunology · 2023Review
- Regional Differences in Kawasaki Disease Incidence Reduction Before and After the Onset of the Coronavirus Disease 2019 Pandemic.The Journal of pediatrics · 2022Article
- [Incidence of Kawasaki disease before and during the covid-19 pandemic in Peru].Revista colombiana de reumatologia · 2022Article
- Epidemiological and Clinical Features of Kawasaki Disease During the COVID-19 Pandemic in the United States.JAMA network open · 2022Article
- Changes in the Clinical Characteristics of Kawasaki Disease After Coronavirus Disease (COVID-19) Pandemic: A Database Analysis.Journal of Korean medical science · 2022Observational
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Authors and funding
10 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Epidemiological studies in Kawasaki disease (KD) have suggested infectious aetiology. During the COVID-19 pandemic, measures for mitigating SARS-CoV-2 transmission also suppress the circulation of other contagious microorganisms. The primary objective is to compare the number and incidence of KD before and during the COVID-19 pandemic in Japan, and the secondary objective is to investigate temporal association between the KD epidemiology and activities of SARS-CoV-2 and other viral and bacterial infections. Methods: A retrospective cohort study was conducted between 2016 and 2020 in Kobe, Japan. We collected information of hospitalised KD children in Kobe. Child population was identified through the resident registry system. Activity of COVID-19 and 11 other infectious diseases was derived from a public health monitoring system. Monthly change of KD incidence was analysed using a difference-in-difference regression model. Results: Throughout the study period, 1027 KD children were identified. KD had begun to decline in April 2020, coinciding with the beginning of the COVID-19 pandemic. The number of KD cases (n=66) between April and December 2020 was 40% of the average in the same period in 2016-2019 (165/year). Annual KD incidence was 315, 300, 353, 347 and 188/100 000 children aged 0-4 years in 2016-2020, respectively. The difference-in-difference value of KD incidence was significantly reduced in the fourth quarter in 2020 (-15.8, 95% CI -28.0 to -3.5), compared with that in 2016-2019. Sentinel surveillance showed a marked decrease of all infectious diseases except exanthema subitum after the beginning of the COVID-19 pandemic. There were 86 COVID-19 cases aged <10 years and no KD children associated with COVID-19. Conclusion: This study showed that the number and incidence of KD was dramatically reduced during the COVID-19 pandemic in Japan. This change was temporally associated with decreased activities of various infectious diseases other than COVID-19, supporting the hypothesis of infection-triggered pathogenesis in KD.
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