Evidence map›Paper›PMID 33884281›Full record

ArticleOncoscience2021

The helix-loop-helix transcriptional regulator Id4 is required for terminal differentiation of luminal epithelial cells in the prostate.

Dhanushka Hewa Bostanthirige, Shravan K Komaragiri, Jugal B Joshi, Majid Alzahrani, Isha Saini, Sanjay Jain, Nathan J Bowen, Matthew C Havrda, Jaideep Chaudhary

Open access · diamondAbstract read
In one paragraph

Article in Oncoscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Dhanushka Hewa BostanthirigeCenter for Cancer Research and Therapeutics Development, Clark Atlanta University, Atlanta GA, USA.
Shravan K KomaragiriCenter for Cancer Research and Therapeutics Development, Clark Atlanta University, Atlanta GA, USA.
Jugal B JoshiCenter for Cancer Research and Therapeutics Development, Clark Atlanta University, Atlanta GA, USA.
Majid AlzahraniCenter for Cancer Research and Therapeutics Development, Clark Atlanta University, Atlanta GA, USA.
Isha SainiLifeline Pathology Lab and Diagnostic Center, Karnal, India.
Sanjay JainMorehouse School of Medicine, Atlanta, GA, USA.
Nathan J BowenCenter for Cancer Research and Therapeutics Development, Clark Atlanta University, Atlanta GA, USA.
Matthew C HavrdaGeisel School of Medicine, Hanover, NH, USA.
Jaideep ChaudharyCenter for Cancer Research and Therapeutics Development, Clark Atlanta University, Atlanta GA, USA.
Center for Cancer Research · USClark Atlanta University · USDartmouth College · USLifeline Hospital · INMorehouse School of Medicine · US

Funding

TRAINNING COREP20MD002285 · NIMHD · CLARK ATLANTA UNIVERSITY · PI KHAN, SHAFIQ A · 2007 to 2016
$10.9M
Technologies/Resources for Core LaboratoriesG12MD007590 · NIMHD · CLARK ATLANTA UNIVERSITY · PI KHAN, SHAFIQ A · 2012 to 2018
$7.6M
Inhibitor of Differentiation Gene Expression and Function in Prostate CellsR01CA128914 · NCI · CLARK ATLANTA UNIVERSITY · PI CHAUDHARY, JAIDEEP · 2009 to 2013
$1.4M
NCI NIH HHS R01 CA128914NIMHD NIH HHS G12 MD007590NIMHD NIH HHS P20 MD002285
6 · The paper itself

Abstract

Inhibitor of differentiation 4 (Id4), a member of the helix-loop-helix family of transcriptional regulators has emerged as a tumor suppressor in prostate cancer. In this study we investigated the effect of loss of Id4 (

Indexed as

androgen receptorID4prostate cancerPten

Identifiers

PMID33884281
PMCPMC8045964
OpenAlexW3155929859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.