ArticleInternational journal of hypertension2021
The Effects of Renal Nerve Denervation on Blood Pressure and Target Organs in Different Hypertensive Rat Models.
Article in International journal of hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 4 citations in OpenAlex.
- Unilateral chemical ablation of the adrenal gland lowers blood pressure and alleviates target organ damage in spontaneously hypertensive rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
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7 authors at 1 institution in 1 country.
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Abstract
backgroundHypertension contributes to the progression of cardiac remodeling and renal damage. In turn, renal sympathetic hyperactivation showed elevated sympathetic nervous system activity and led to blood pressure increase in certain patients. The purpose of this study was to observe the effect of renal nerve denervation on blood pressure and target organ changes in two hypertensive rat models.
methodsHypertensive rats were randomly divided into a renal denervation (RDN) group and sham operation group. Wistar-Kyoto (WKY) rats of the same age were set as the baseline control group. In the secondary hypertension model, SD rats were randomly divided into five groups. Blood pressure and bodyweight were measured every week until they were euthanized.
resultsThe two rat models underwent RDN at key timepoints. At these timepoints, the hearts and kidneys were collected for norepinephrine and angiotensin II measurements and histological analysis.
conclusionRDN performed before development of hypertension showed a significant antihypertensive effect on the secondary hypertension model.
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