Evidence map›Paper›PMID 33884016›Full record

ArticleIranian journal of parasitology

Next-Generation Sequencing Reveals That Oxidative Phosphorylation Might Be a Key Pathway Differently Expressed in the Third and Fourth Stages Larvae of

Yue Guo, Hong Chang Zhou, Ying Dong, Hai Yan Dong, Yun Liang Yao, Jing Qian, Hui Zhang, Xiao Yu Li, Zhong Shan Zhang, Han Bing Lin and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of parasitology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Transcriptome Profiling of Male AdultIranian journal of parasitology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yue GuoSchool of Medicine, Huzhou University, Huzhou Cent Hosp, 759 Er Huan Rd, Huzhou, Zhejiang, China.
Hong Chang ZhouSchool of Medicine, Huzhou University, Huzhou Cent Hosp, 759 Er Huan Rd, Huzhou, Zhejiang, China.
Ying DongSchool of Medicine, Huzhou University, Huzhou Cent Hosp, 759 Er Huan Rd, Huzhou, Zhejiang, China.
Hai Yan DongSchool of Medicine, Huzhou University, Huzhou Cent Hosp, 759 Er Huan Rd, Huzhou, Zhejiang, China.
Yun Liang YaoSchool of Medicine, Huzhou University, Huzhou Cent Hosp, 759 Er Huan Rd, Huzhou, Zhejiang, China.
Jing QianSchool of Medicine, Huzhou University, Huzhou Cent Hosp, 759 Er Huan Rd, Huzhou, Zhejiang, China.
Hui ZhangSchool of Medicine, Huzhou University, Huzhou Cent Hosp, 759 Er Huan Rd, Huzhou, Zhejiang, China.
Xiao Yu LiSchool of Medicine, Huzhou University, Huzhou Cent Hosp, 759 Er Huan Rd, Huzhou, Zhejiang, China.
Zhong Shan ZhangKey Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, Huzhou University, Huzhou, Zhejiang, China.
Han Bing LinSchool of Medicine, Huzhou University, Huzhou Cent Hosp, 759 Er Huan Rd, Huzhou, Zhejiang, China.
Tian ZhouSchool of Medicine, Huzhou University, Huzhou Cent Hosp, 759 Er Huan Rd, Huzhou, Zhejiang, China.
Meng Jia ZhaoSchool of Medicine, Huzhou University, Huzhou Cent Hosp, 759 Er Huan Rd, Huzhou, Zhejiang, China.
Tang Qin JiSchool of Medicine, Huzhou University, Huzhou Cent Hosp, 759 Er Huan Rd, Huzhou, Zhejiang, China.
Run Ze WangSchool of Medicine, Huzhou University, Huzhou Cent Hosp, 759 Er Huan Rd, Huzhou, Zhejiang, China.
Feng Ping ZhangSchool of Medicine, Huzhou University, Huzhou Cent Hosp, 759 Er Huan Rd, Huzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhen

methodsThe transcriptome differences of the third and fourth stages of

resultsOverall, 137 956 488 clean reads and 20 406 213 373 clean bases of the two stages larvae were produced. Based on the queries against the Gene Ontology (GO), NCBI non-redundant protein sequences (Nr), Swissprot, and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases, 14 204 differentially expressed genes (DEGs) were predicted. GO enrichment analysis revealed 5660 DEGs with the top s categories as followings: biological process (GO:0008150, related to 5345 DEGs), cellular component (GO:0005575, related to 5297 DEGs), molecular function (GO:0003674, related to 5290 DEGs). In KEGG enrichment analysis, 116 genes were related to oxidative phosphorylation and 49 genes involved in the glycolytic process.

conclusionMetabolism changes, especially oxidative phosphorylation and glycolysis, might play a key role in

Indexed as

Angiostrongylus cantonensisFourth stage larvaeNext-generation sequencingThird stage larvaeTranscriptional sequencing

Identifiers

PMID33884016
PMCPMC8039486

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.