Evidence map›Paper›PMID 33883929›Full record

ArticleInternational journal of general medicine2021

Risk of Colorectal Carcinoma May Predispose to the Genetic Variants of the

Ikhlas A Sindi, Ahmed O Babalghith, Mohammed T Tayeb, Ahmad H Mufti, Hind Naffadi, Samar N Ekram, Ezzeldin N Elhawary, Munaifah Alenezi, Nasser A Elhawary

Open access · goldAbstract read
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Article in International journal of general medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Variations inInternational journal of general medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Ikhlas A SindiDepartment of Biotechnology, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Ahmed O BabalghithDepartment of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, Mecca, 21955, Saudi Arabia.
Mohammed T TayebDepartment of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, Mecca, 21955, Saudi Arabia.ORCID 0000-0001-9238-3747
Ahmad H MuftiDepartment of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, Mecca, 21955, Saudi Arabia.
Hind NaffadiCommon Science, First Year Deanship, Umm Al-Qura University, Mecca, Saudi Arabia.
Samar N EkramDepartment of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, Mecca, 21955, Saudi Arabia.
Ezzeldin N ElhawaryMS Genomic Medicine Program, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.ORCID 0000-0002-8691-1459
Munaifah AleneziDepartment of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, Mecca, 21955, Saudi Arabia.
Nasser A ElhawaryDepartment of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, Mecca, 21955, Saudi Arabia.ORCID 0000-0002-9137-351X
Umm al-Qura University · SAAin Shams University · EGKing Abdulaziz University · SASouthampton General Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeColorectal carcinoma (CRC) represents a considerable public health burden in Saudi Arabia. Several candidate genes and genetic variants have been associated with morbidity and mortality among patients with CRC. We explored whether allelic variants of the PATIENTS AND

methodsDNA from buccal cells of 158 participants (80 with CRC and 78 healthy controls) were analyzed for five SNPs using conventional PCR and TaqMan genotyping assays. The SNPStats software was utilized to choose the best interactive inheritance mode for selected SNPs (https://www.snpstats.net).

resultsThe mean age of diagnosis was 62.4±13.5 years (range, 40-83 years), with those aged 71-80 years and those aged 40-50 years accounting for the most diagnoses (35.7% and 28.6% of diagnosis, respectively). The

conclusionThe

Indexed as

age at diagnosiscolorectal carcinomalinkage disequilibriumnonsmokerssingle nucleotide polymorphismTaqMan genotyping

Identifiers

PMID33883929
PMCPMC8055278
OpenAlexW3156358039

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.