Evidence map›Paper›PMID 33883880›Full record

Trial reportDrug design, development and therapy2021

Comparison of Outcomes in Patients with Obesity Between Two Administration Routes of Omeprazole After Laparoscopic Sleeve Gastrectomy: An Open-Label Randomized Clinical Trial.

Qin Tan, Yanding Gao, Pin Zhang, Yan Huo, Yihan Lu, Weifeng Huang

Open access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug design, development and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Qin Tan *Department of Critical Care, The Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.ORCID 0000-0002-2263-9804
Yanding Gao *Department of Critical Care, The Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Pin ZhangDepartment of General Surgery, The Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Yan HuoDepartment of Pharmacy, The Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Yihan LuDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, People's Republic of China.
Weifeng HuangDepartment of Critical Care, The Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Shanghai Jiao Tong University · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe effect of different administration routes of omeprazole remains unclear on the recovery in patients with obesity after laparoscopic sleeve gastrectomy (LSG).

methodsWe designed a randomized clinical trial enrolling 120 patients with a BMI≥32.5 kg/m

resultsPatients in the two groups showed no difference in the AUC curves (P=0.25), but group A had significantly higher peak concentration (P<0.001), and shorter time to reach peak concentration after administration (P<0.001), compared to group B. Before and after the administration of omeprazole, the average change in intragastric pH was much lower in group A (0.031 ± 0.61) than in group B (0.48 ± 0.74) (P=0.004). The incidence of gastrointestinal symptoms was similar between the two groups (P=0.85); however, the average duration of remaining symptoms was longer in group A (3.97 months; 95% CI, 2.90-5.04) than in group B (2.82 months; 95% CI, 2.01-3.63) (P=0.04).

conclusionContinuous micropump infusion of omeprazole may improve the outcomes in patients with obesity after LSG.

trial registrationChina Clinical Trial Registration Center (ChiCTR), ChiCTR-IPR-17013365. Registered 13 November 2017. http://www.chictr.org.cn/showproj.aspx?proj=22892.

Indexed as

GastrectomyHumansInfusions, IntravenousInjections, IntravenousLaparoscopyObesityOmeprazoleOmeprazolegastrointestinal symptomslaparoscopic sleeve gastrectomyobesityomeprazole

Identifiers

PMID33883880
PMCPMC8055283
OpenAlexW3154615857

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.